Glidobactins A, B and C, new antitumor antibiotics. II. Structure elucidation

Glidobactins A, B and C, new antitumor antibiotics. II. Structure elucidation

The structures of new antitumor antibiotics, glidobactins A (Ia), B (Ib) and C (Ic) were elucidated by a combination of chemical and enzymatic degradations and spectral analyses. They have in common a cyclized tripeptide nucleus composed of L-threonine, 4(S)-amino-2(E)-pentenoic acid and erythro-4-h...

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Bibliographic Details
Published in:Journal of antibiotics Vol. 41; no. 10; p. 1338
Main Authors: Oka, M, Yaginuma, K, Numata, K, Konishi, M, Oki, T, Kawaguchi, H
Format: Journal Article
Language:English
Published: Japan 1988
Subjects:
Amino Acids
Antibiotics, Antineoplastic
Chemical Phenomena
Chemistry
Fatty Acids
Hydrolysis
Lysine - analogs & derivatives
Magnetic Resonance Spectroscopy
Peptides, Cyclic
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Summary:The structures of new antitumor antibiotics, glidobactins A (Ia), B (Ib) and C (Ic) were elucidated by a combination of chemical and enzymatic degradations and spectral analyses. They have in common a cyclized tripeptide nucleus composed of L-threonine, 4(S)-amino-2(E)-pentenoic acid and erythro-4-hydroxy-L-lysine, and differ from each other in the unsaturated fatty acid moiety attached to the peptide.
ISSN:0021-8820
DOI:10.7164/antibiotics.41.1338