Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives

• Published in: Skin research and technology Vol. 21; no. 3; p. 333
• Main Authors: Incel, P, Gurel, M S, Erdemir, A V
• Format: Journal Article
• Language: English
• Published: England 01-08-2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Dermoscopy - methods; Female; Humans; Image Enhancement - methods; Male; Microscopy, Confocal - methods; Middle Aged; Neovascularization, Pathologic - classification; Neovascularization, Pathologic - pathology; Observer Variation; Pigmentation Disorders - pathology; Reproducibility of Results; Sensitivity and Specificity; Skin Neoplasms - classification; Skin Neoplasms - pathology; Young Adult; reflectance confocal microscopy; skin neoplasm; vascularity; vascular morphology; nonpigmented tumor
• DOI: 10.1111/srt.12197
• EISSN: 1600-0846

The characteristic vascular patterns of nonpigmented skin tumors have been established by dermoscopy. Recently, in vivo reflectance confocal microscopy (RCM) has become an established method for the noninvasive examination of skin tumors.
Determination of the value of RCM on the vascularity of nonpigmented skin tumors.
One hundred and twenty two tumoral lesions have been evaluated by RCM in terms of their vascular structures. They were classified in five groups as basal cell carcinoma (BCC), seborrheic keratosis (SK), squamous cell carcinoma (SCC)/keratoacanthoma, actinic keratosis (AK)/Bowen disease and others. Vascular morphologies were investigated as curved linear, straight linear, branching, tubular/canalicular, round and polymorphic vessels in six types.
Relatively, small number of patients with some tumor subgroups is limitation. Larger prospective studies are required before firm conclusions can be drawn.
Excellent compliance was obtained in interobserver analysis. Branching vessels had a high predictive value for basal cell carcinoma (BCC) with RCM (P < 0.001). Also vascular polymorphism was more frequently (69.4%) seen in malignant nonpigmented tumors (P < 0.05) than benign nonpigmented tumors (30.6%). Furthermore, vessels with opposite flows had high predictive value for malignant tumors (P < 0.05) compared with benign tumors.
Vascular properties can be evaluated in the diagnosis of nonpigmented tumoral skin lesions via RCM.