A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 57; no. 12; pp. 695 - 698
• Main Authors: Ravert, Hayden T., Holt, Daniel P., Dannals, Robert F.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-10-2014; Wiley Subscription Services, Inc
• Subjects: Chemistry Techniques, Synthetic - instrumentation; Chemistry Techniques, Synthetic - methods; fluorine-18; microwave; Microwaves; Organophosphorus Compounds - chemical synthesis; phosphonium; positron emission tomography; Radiopharmaceuticals - chemical synthesis; fluorine-18; positron emission tomography; microwave; phosphonium
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/jlcr.3241

The 4‐[18F]‐fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]‐fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4‐[18F]‐fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/µmole at end of synthesis.
The 4‐[18F]‐fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]‐fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4‐[18F]‐fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with high specific radioactivity at end of synthesis.