A Pilot Study: Effects of Dietary Supplementation with α-Linolenic Acid-Enriched Perilla Seed Oil on Bronchial Asthma
N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of as...
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| Published in: | Allergology international Vol. 46; no. 3; pp. 181 - 185 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
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Elsevier B.V
1997
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| Abstract | N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P<0.05). The generation of leukotriene B4 (LTB4) by peripheral leukocytes stimulated with the Ca2+ ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5Xl06 cells by dietary supplementation (P<0.05). The generation of leukotriene C4 (LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8ng/5x106 cells after supplementation with perilla seed oil (P<0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma. |
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| AbstractList | N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P<0.05). The generation of leukotriene B4 (LTB4) by peripheral leukocytes stimulated with the Ca2+ ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5Xl06 cells by dietary supplementation (P<0.05). The generation of leukotriene C4 (LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8ng/5x106 cells after supplementation with perilla seed oil (P<0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma. N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P<0.05). The generation of leukotriene B4 (LTB4) by peripheral leukocytes stimulated with the Ca2+ ionophore A23187 was significantly suppressed from 77.6 to 41.6 ng/5Xl06 cells by dietary supplementation (P<0.05). The generation of leukotriene C4 (LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106 cells after supplementation with perilla seed oil (P<0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma. |
| Author | Hosaki, Yasuhiro Tanizaki, Yoshiro Tsuji, Takao Ashida, Kozo Mitsunobu, Fumihiro Yokota, Satoshi Mifune, Takashi Tsugeno, Hirofumi |
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| Keywords | bronchial asthma peak flow leukotriene C4 perilla seed oil leukotriene B4 |
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| References | Lam (10.2332/allergolint.46.181_bb0075) 1988; 81 Tanizaki (10.2332/allergolint.46.181_bb0060) 1993; 16 Pauwels (10.2332/allergolint.46.181_bb0105) 1989; 19 Arm (10.2332/allergolint.46.181_bb0035) 1988; 43 Dahlen (10.2332/allergolint.46.181_bb0110) 1983; 866 Tanizaki (10.2332/allergolint.46.181_bb0005) 1993; 101 Prescott (10.2332/allergolint.46.181_bb0120) 1984; 259 Walker (10.2332/allergolint.46.181_bb0085) 1991; 88 Thien (10.2332/allergolint.46.181_bb0015) 1995; 52 Kirby (10.2332/allergolint.46.181_bb0080) 1987; 136 Kelly (10.2332/allergolint.46.181_bb0100) 1988; 43 Tanizaki (10.2332/allergolint.46.181_bb0055) 1993; 116 Tanizaki (10.2332/allergolint.46.181_bb0070) 1990; 29 Thien (10.2332/allergolint.46.181_bb0050) 1993; 147 Ferretti (10.2332/allergolint.46.181_bb0025) 1993; 4 Lee (10.2332/allergolint.46.181_bb0115) 1984; 75 Knapp (10.2332/allergolint.46.181_bb0030) 1995; 14 Dry (10.2332/allergolint.46.181_bb0045) 1991; 98 Sanders (10.2332/allergolint.46.181_bb0020) 1993; 52 Wenzel (10.2332/allergolint.46.181_bb0010) 1991; 87 Durham (10.2332/allergolint.46.181_bb0095) 1996; 97 Jemionek (10.2332/allergolint.46.181_bb0065) 1978; 19 Aalbers (10.2332/allergolint.46.181_bb0090) 1993; 147 Arm (10.2332/allergolint.46.181_bb0040) 1989; 39 |
| References_xml | – volume: 39 start-page: 1395 year: 1989 ident: 10.2332/allergolint.46.181_bb0040 article-title: The effects of dietary supplementation with fish oil on the airways response to inhaled allergen in bronchial asthma publication-title: Am. Rev. Respir. Dis. doi: 10.1164/ajrccm/139.6.1395 contributor: fullname: Arm – volume: 101 start-page: 196 year: 1993 ident: 10.2332/allergolint.46.181_bb0005 article-title: Changes in the proportions of bronchoalveolar lymphocytes, neutrophils and basophilic cells and the release of histamine and leukotrienes from bronchoalveolar cells in patients with steroid-dependent intractable asthma publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000236519 contributor: fullname: Tanizaki – volume: 19 start-page: 395 year: 1989 ident: 10.2332/allergolint.46.181_bb0105 article-title: The relationship between airway inflammation and bronchial hyperresponsiveness publication-title: Clin. Exp. Allergy doi: 10.1111/j.1365-2222.1989.tb02404.x contributor: fullname: Pauwels – volume: 259 start-page: 7615 year: 1984 ident: 10.2332/allergolint.46.181_bb0120 article-title: The effect of eicosapentaenoic acid on leukotriene B production by human neutrophils publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)42835-3 contributor: fullname: Prescott – volume: 87 start-page: 540 year: 1991 ident: 10.2332/allergolint.46.181_bb0010 article-title: Bronchoalveolar lavage fluid mediator levels 5min after allergen challenge in atopic subjects with asthma: Relationship to the development of late asthmatic responses publication-title: J. Allergy Clin. Immunol. doi: 10.1016/0091-6749(91)90013-E contributor: fullname: Wenzel – volume: 116 start-page: 99 year: 1993 ident: 10.2332/allergolint.46.181_bb0055 article-title: Histamine and leukotriene C4 levels in bronchoalveolar lavage (BAL) fluid in patients with bronchial asthma publication-title: Jpn. J. Clin. Immunol. doi: 10.2177/jsci.16.99 contributor: fullname: Tanizaki – volume: 52 start-page: 457 year: 1993 ident: 10.2332/allergolint.46.181_bb0020 article-title: Marine oils: Metabolic effects and role in human nutrition publication-title: Proc. Nutr. Soc doi: 10.1079/PNS19930086 contributor: fullname: Sanders – volume: 147 start-page: 1138 year: 1993 ident: 10.2332/allergolint.46.181_bb0050 article-title: Dietary fish oil effects on seasonal hay fever and asthma in pollen- sensitive subjects publication-title: Am. Rev. Respir. Dis. doi: 10.1164/ajrccm/147.5.1138 contributor: fullname: Thien – volume: 75 start-page: 1922 year: 1984 ident: 10.2332/allergolint.46.181_bb0115 article-title: Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase products by ionophore- activated human neutrophils publication-title: J. Clin. Invest. doi: 10.1172/JCI111612 contributor: fullname: Lee – volume: 43 start-page: 82 year: 1988 ident: 10.2332/allergolint.46.181_bb0035 article-title: Effect of dietary supplementation with fish oil on mild asthma publication-title: Thorax doi: 10.1136/thx.43.2.84 contributor: fullname: Arm – volume: 81 start-page: 711 year: 1988 ident: 10.2332/allergolint.46.181_bb0075 article-title: Release of leukotrienes in patients with bronchial asthma publication-title: J. Allergy Clin. Immunol doi: 10.1016/0091-6749(88)91043-3 contributor: fullname: Lam – volume: 136 start-page: 379 year: 1987 ident: 10.2332/allergolint.46.181_bb0080 article-title: Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects publication-title: Am. Rev. Respir. Dis. doi: 10.1164/ajrccm/136.2.379 contributor: fullname: Kirby – volume: 14 start-page: 18 year: 1995 ident: 10.2332/allergolint.46.181_bb0030 article-title: Omega-3 fatty acids in respiratory diseases: A review publication-title: J. Am. Coll. Nutr doi: 10.1080/07315724.1995.10718468 contributor: fullname: Knapp – volume: 43 start-page: 684 year: 1988 ident: 10.2332/allergolint.46.181_bb0100 article-title: Numbers and activity of inflammatory cell in bronchoalveolar lavage fluid in asthma, and their relationship to airway hyperresponsiveness publication-title: Thorax doi: 10.1136/thx.43.9.684 contributor: fullname: Kelly – volume: 866 start-page: 207 year: 1983 ident: 10.2332/allergolint.46.181_bb0110 article-title: Contractile activities of several cystein-containing leukotrienes in the guinea pig lung strip publication-title: Eur. J. Pharmacol. contributor: fullname: Dahlen – volume: 88 start-page: 934 year: 1991 ident: 10.2332/allergolint.46.181_bb0085 article-title: Activated T cells and eosinophils in bronchoalveolar lavages from subjects with asthma correlated with disease severity publication-title: J. Allergy Clin. Immunol. doi: 10.1016/0091-6749(91)90251-I contributor: fullname: Walker – volume: 52 start-page: 271 year: 1995 ident: 10.2332/allergolint.46.181_bb0015 article-title: Eicosanoids and asthma: An update publication-title: Prostaglandins Leukot. Essent. Fatty Acids doi: 10.1016/0952-3278(95)90027-6 contributor: fullname: Thien – volume: 16 start-page: 44 year: 1993 ident: 10.2332/allergolint.46.181_bb0060 article-title: Association of asthma with serum IgE levels and aging. Bronchoalveolar cells and the release of histamine and leukotrienes, LTC4 and LTB4, from leukocytes publication-title: Jpn. J. Clin. Immunol. doi: 10.2177/jsci.16.44 contributor: fullname: Tanizaki – volume: 97 start-page: 1356 year: 1996 ident: 10.2332/allergolint.46.181_bb0095 article-title: Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocyte and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ publication-title: J. Allergy Clin. Immunol doi: 10.1016/S0091-6749(96)70205-1 contributor: fullname: Durham – volume: 4 start-page: 695 year: 1993 ident: 10.2332/allergolint.46.181_bb0025 article-title: Fish oil supplementation reduces excretion of; 2,3-dinor-oxo- PGFα and 1 -dehydro-thromboxane B2/2, 3-dinor-oxo- PGFα excretion ratio in adult men publication-title: J. Nutr. Biochem doi: 10.1016/0955-2863(93)90109-A contributor: fullname: Ferretti – volume: 29 start-page: 356 year: 1990 ident: 10.2332/allergolint.46.181_bb0070 article-title: Release of heparin-like substance and histamine from basophilic leukocytes separated by counterflow centrifugation elutriation publication-title: Jpn. J. Med doi: 10.2169/internalmedicine1962.29.356 contributor: fullname: Tanizaki – volume: 98 start-page: 156 year: 1991 ident: 10.2332/allergolint.46.181_bb0045 article-title: Effect of a fish oil diet on asthma: Results of a 1 year double blind study publication-title: Int. Arch. Allergy Appl. Immunol. doi: 10.1159/000235421 contributor: fullname: Dry – volume: 147 start-page: 76 year: 1993 ident: 10.2332/allergolint.46.181_bb0090 article-title: Bronchial lavage and bronchoalveolar lavage in allergen-induced single early and dual asthmatic responder publication-title: Am. Rev. Respir. Dis. doi: 10.1164/ajrccm/147.1.76 contributor: fullname: Aalbers – volume: 19 start-page: 120 year: 1978 ident: 10.2332/allergolint.46.181_bb0065 article-title: Technique for increased granulocyte recovery from human whole blood by counterflow centrifugation elutriation. 1 publication-title: In vitro analysis. Transfusion contributor: fullname: Jemionek |
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| Title | A Pilot Study: Effects of Dietary Supplementation with α-Linolenic Acid-Enriched Perilla Seed Oil on Bronchial Asthma |
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