An Epstein-Barr virus-associated pulmonary lymphoproliferative disorder as complication of immunosuppression

Inherited or acquired immunodeficiencies as well as autoimmune diseases treated with cytotoxic drugs are associated with an increased incidence of lymphoma. Non-Hodgkin's lymphomas that occur in the context of drug-induced immunosuppression, acquired or congenital immunodeficiency, are frequent...

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Bibliographic Details
Published in:	Netherlands journal of medicine Vol. 57; no. 4; p. 165
Main Authors:	Van Haarlem, S W, Verpalen, M C, Van Gorp, J M, Hoekstra, J B, Van Den Bosch, J M
Format:	Journal Article
Language:	English
Published:	Netherlands 01-10-2000
Subjects:	Arthritis, Rheumatoid - drug therapy Biopsy, Needle Epstein-Barr Virus Infections - complications Humans Immunocompromised Host Immunosuppressive Agents - adverse effects Lung Neoplasms - chemically induced Lung Neoplasms - diagnosis Lung Neoplasms - immunology Lung Neoplasms - virology Lymphoma, B-Cell - chemically induced Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - immunology Lymphoma, B-Cell - virology Male Methotrexate - adverse effects Middle Aged Risk Factors Tomography, X-Ray Computed
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Summary:	Inherited or acquired immunodeficiencies as well as autoimmune diseases treated with cytotoxic drugs are associated with an increased incidence of lymphoma. Non-Hodgkin's lymphomas that occur in the context of drug-induced immunosuppression, acquired or congenital immunodeficiency, are frequently associated with Epstein-Barr virus infection. This report describes the occurrence of an Epstein-Barr virus associated pulmonary B cell lymphoma in a patient with longstanding rheumatoid arthritis treated with methotrexate.
ISSN:	0300-2977
DOI:	10.1016/S0300-2977(00)00065-6