Alternative moving window factor analysis for comparison analysis between complex chromatographic data

• Published in: Journal of Chromatography A Vol. 1107; no. 1; pp. 273 - 285
• Main Authors: Zeng, Zhong-Da, Liang, Yi-Zeng, Wang, Ya-Li, Li, Xiao-Ru, Liang, Lu-Ming, Xu, Qing-Song, Zhao, Chen-Xi, Li, Bo-Yan, Chau, Foo-Tim
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24-02-2006; Elsevier
• Subjects: Alternative moving window factor analysis (AMWFA); Analytical chemistry; Angelica; Angelica - chemistry; Animals; Biological and medical sciences; Chemistry; Chromatographic methods and physical methods associated with chromatography; Drug pair; Exact sciences and technology; Factor Analysis, Statistical; Gas Chromatography-Mass Spectrometry - methods; General pharmacology; Medical sciences; Metabolic analysis; Multi-component spectral correlative chromatography (MSCC); Other chromatographic methods; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - administration & dosage; Rabbits; Rhizoma ligustici chuanxiong- radix paeoniae rubra ( RLC- RPR); Asia; China; Multi-component spectral correlative chromatography (MSCC); Angelica; Rhizoma ligustici chuanxiong- radix paeoniae rubra ( RLC- RPR); Metabolic analysis; Alternative moving window factor analysis (AMWFA); Drug pair; Biological fluid; Rhizoma ligustici chuanxiong-radix paeoniae rubra (RLC-RPR); Chemical analysis; Atmospheric pressure; Multicomponent mixture; HPLC chromatography; Rabbit; Blood; Medicinal plant; Blood plasma; Folk medicine; Dicotyledones; Angiospermae; Rhizome; Below ground plant part; Factor analysis; Root; Coupled method; Pharmacognosy; Oral administration; Oral form; Volatile organic compound; Lagomorpha; Chemical ionization; Vertebrata; Reversed phase chromatography; Mammalia; Ultraviolet detector; Animal; Quality control; Plant origin; Dosage form; Spermatophyta; Umbelliferae; Paeoniaceae; Pharmacokinetics; Mass spectrometry; Chemometrics; Comparative study
• ISSN: 0021-9673
• DOI: 10.1016/j.chroma.2005.12.015

In this investigation, a novel chemometric method is developed for the analysis of five possible relationships of components or spectral features between two correlative but different hyphenated chromatographic systems. It is very helpful for comparison study of components present in different complex systems in both chemistry and systems biology. The proposed method, named alternative moving window factor analysis (AMWFA), could be utilized to determine the number of common components between different samples and then to identify their corresponding spectra half-automatically. AMWFA can alternatively be employed to mind for the selective information hiding in anyone of the two compared data
X and
Y, and to self-verify the resolution results by changing the extracted target matrices in analysis. From the results of comparison of simulated hyphenated chromatographic data, volatile chemical components in drug pair
rhizoma ligustici chuanxiong-
radix paeoniae rubra (
RLC-
RPR) and its single herbal medicines, and analysis of
Angelica oral solution and its plasma sample after oral intake to rabbit, powerful ability of the proposed method is shown.