Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis

Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A str...

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Bibliographic Details
Published in:	Journal of biomedical optics Vol. 9; no. 2; p. 404
Main Authors:	Hocdé, S, Loréal, O, Sire, O, Boussard-Plédel, C, Bureau, B, Turlin, B, Keirsse, J, Leroyer, P, Lucas, J
Format:	Journal Article
Language:	English
Published:	United States 01-03-2004
Subjects:	Animals Diagnostic Tests, Routine Fiber Optic Technology Infrared Rays Liver - metabolism Mice Optical Fibers Sensitivity and Specificity Spectrum Analysis - instrumentation
Online Access:	Get more information
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Summary:	Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A strict control of the fiber diameter in the tapered sensing zone allows high sensitivity and wide spectral range exploration from 800 to 3000 cm(-1). Then, merely in depositing the mouse liver biopsies on the fiber, this device has enable us to differentiate between tumorous and healthy tissues.
ISSN:	1083-3668
DOI:	10.1117/1.1646415