SP1-induced lncRNA DUBR promotes stemness and oxaliplatin resistance of hepatocellular carcinoma via E2F1-CIP2A feedback

Oxaliplatin-based chemotherapy is widely used to treat advanced hepatocellular carcinoma (HCC), but many patients develop drug resistance that leads to tumor recurrence. Cancer stem cells (CSCs) are known to contribute to chemoresistance, the underlying mechanism, however, remains largely unknown. I...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer letters Vol. 528; pp. 16 - 30
Main Authors:	Liu, S, Bu, Xy, Kan, Anna, Luo, L, Xu, Yj, Chen, Hl, Lin, Xj, Lai, Zc, Wen, Ds, Huang, Lc, Shi, M
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-03-2022 Elsevier Limited
Subjects:	Animals Antibodies Antigens Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Autoantigens - metabolism Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell cycle Chemoresistance Chemotherapy Clinical medicine Drug resistance DUBR E2F1 protein E2F1 Transcription Factor - metabolism Epigenetics Gene regulation Hepatocellular carcinoma Humans Hybridization Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Long noncoding RNA Mass spectrometry Medical prognosis Membrane Proteins - metabolism Mice Mice, Nude miRNA Notch1 protein Oxaliplatin Oxaliplatin - pharmacology Oxaliplatin - therapeutic use Phosphoprotein phosphatase Protein phosphatase Proteins RNA polymerase RNA, Long Noncoding - metabolism Scientific imaging Signal transduction Sp1 protein Sp1 Transcription Factor - metabolism Stem cells Stemness maintenance Transcription United States > US China Singapore DUBR ChIRP OS IHC Chemoresistance LncRNA HCC CIP2A ChIP ACTB TCGA CSC TKI ceRNAs EMSA IC50 FISH RIP OXA Long noncoding RNA Stemness maintenance RFS
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!