Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruse...

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Bibliographic Details
Published in:Natural product research Vol. 35; no. 18; pp. 3161 - 3165
Main Authors: da Silva, Marlene Lourenço, Stehmann, João Renato, Serafim, Mateus Sá Magalhães, Vale, Valdicley Vieira, Gontijo, Douglas Costa, Brandão, Geraldo Célio, Kroon, Erna Geessien, de Oliveira, Alaíde Braga
Format: Journal Article
Language:English
Published: Taylor & Francis 17-09-2021
Subjects:
dengue virus
Himatanthus bracteatus
plumieride
spectroscopic analyses
yellow fever virus
Zika virus
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Summary:The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1690487