The electrostability and electrically assisted delivery of an organophosphate pretreatment (physostigmine) across human skin in vitro

Physostigmine is a tertiary carbamate that is utilised as a pretreatment against organophosphate intoxication. Oral delivery of physostigmine is not practical due to high first pass metabolism and short elimination half life. Transdermal administration of physostigmine may circumvent such problems....

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Bibliographic Details
Published in:	Journal of controlled release Vol. 68; no. 2; pp. 157 - 166
Main Authors:	Rowland, Caroline A, Chilcott, Robert P
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 10-08-2000 Elsevier
Subjects:	Biological and medical sciences Cholinesterase Inhibitors - administration & dosage Electroporation General pharmacology Human skin absorption Humans In vitro In Vitro Techniques Iontophoresis Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physostigmine Physostigmine - administration & dosage Physostigmine - pharmacokinetics Skin Absorption Iontophoresis Human skin absorption Electroporation Physostigmine In vitro Antiglaucomatous agent Human Delivery system Stability Transdermal system Pharmaceutical technology Permeation Epidermis Parasympathomimetic Absorption Dosage form Skin Carbamate
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