$Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model$
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Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model

The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy. Repeated seizures were induced in male...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 413; no. 2; pp. 168 - 172
Main Authors:	Höcht, Christian, Lazarowski, Alberto, Gonzalez, Nélida N., Auzmendi, Jerónimo, Opezzo, Javier A.W., Bramuglia, Guillermo F., Taira, Carlos A., Girardi, Elena
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 14-02-2007 Elsevier
Subjects:	3-Mercaptopropionic Acid Animals Anticonvulsants - agonists Anticonvulsants - pharmacokinetics ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Convulsants Disease Models, Animal Drug Resistance - drug effects Drug Resistance - physiology Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - metabolism Extracellular Fluid - drug effects Extracellular Fluid - metabolism Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Male Medical sciences Microdialysis Nervous system (semeiology, syndromes) Neurology Nimodipine Nimodipine - pharmacology Nimodipine - therapeutic use P-glycoprotein Phenytoin Phenytoin - agonists Phenytoin - pharmacokinetics Rats Rats, Wistar Refractory epilepsy Vertebrates: nervous system and sense organs P-glycoprotein Refractory epilepsy Microdialysis Nimodipine Phenytoin Nervous system diseases Epilepsy Central nervous system Glycoprotein Anticonvulsant Cerebral disorder Central nervous system disease Models Hippocampus
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