A single-cell survey of the human first-trimester placenta and decidua

The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known...

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Bibliographic Details
Published in:	Science advances Vol. 4; no. 10; p. eaau4788
Main Authors:	Suryawanshi, Hemant, Morozov, Pavel, Straus, Alexander, Sahasrabudhe, Nicole, Max, Klaas E A, Garzia, Aitor, Kustagi, Manjunath, Tuschl, Thomas, Williams, Zev
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 01-10-2018
Subjects:	Health and Medicine SciAdv r-articles
Online Access:	Get full text
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Summary:	The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Further detailed analysis revealed proliferating subpopulations, enrichment of cell type-specific transcription factors, and putative intercellular communication in the fetomaternal microenvironment. This study provides a blueprint to further the understanding of the roles of these cells in the placenta and decidua for maintenance of early gestation as well as pathogenesis in pregnancy-related disorders.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2375-2548 2375-2548
DOI:	10.1126/sciadv.aau4788