Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-κB activation

Bacterial DNA (bDNA) and lipopolysaccharide (LPS) are potent activators of immune cells such as monocytes and macrophages, which contribute to systemic inflammatory response syndrome (SIRS) and sepsis. Unfortunately, many experimental inflammatory antagonist-based therapies have failed in sepsis tri...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 8; no. 3; pp. 379 - 389
Main Authors:	Li, Bin, Zhang, Rong, Li, Jun, Zhang, Lezhi, Ding, Guofu, Luo, Ping, He, Shengqi, Dong, Yan, Jiang, Weiwei, Lu, Yongling, Cao, Hongwei, Zheng, Jiang, Zhou, Hong
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-03-2008 Elsevier
Subjects:	Animals Antimalarials - pharmacology Artemisinins - pharmacology Artemisinins - therapeutic use Artesunate Bacteremia - drug therapy Biological and medical sciences Cells, Cultured CpG ODN Endotoxins - blood Escherichia coli Infections - drug therapy Female Heat-killed Escherichia coli Interleukin-6 - biosynthesis LPS Male Medical sciences Mice NF-kappa B - metabolism Oligodeoxyribonucleotides - metabolism Pharmacology. Drug treatments Proinflammatory cytokines RNA, Messenger - analysis Sepsis Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use TLR4 TLR9 Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 9 - antagonists & inhibitors Toll-Like Receptor 9 - genetics Tumor Necrosis Factor-alpha - biosynthesis Artesunate Heat-killed Escherichia coli TLR9 Sepsis CpG ODN Proinflammatory cytokines TLR4 LPS Antimalarial Animal model Temperature Toll like receptor 4 Escherichia coli Environmental factor Activation Toll like receptor 9 Prevention Sepsis syndrome Signal transduction Messenger RNA GC rich sequence Lipopolysaccharide Bacteria Transcription factor NFκB Transcription factor Enterobacteriaceae Nucleotide sequence Rodentia Cytokine Inflammation Infection Vertebrata Heat Mammalia Mouse Parasiticide
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