Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons

Alzheimer's disease is linked to increased levels of amyloid beta (Aβ) in the brain, but the mechanisms underlying neuronal dysfunction and neurodegeneration remain enigmatic. Here, we investigate whether organizational characteristics of functional presynaptic vesicle pools, key determinants o...

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Bibliographic Details

Published in:	Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 4; pp. 1263 - 1276
Main Authors:	Biasetti, Luca, Rey, Stephanie, Fowler, Milena, Ratnayaka, Arjuna, Fennell, Kate, Smith, Catherine, Marshall, Karen, Hall, Catherine, Vargas-Caballero, Mariana, Serpell, Louise, Staras, Kevin
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 07-02-2023
Subjects:	Amyloid beta-Peptides - metabolism Hippocampus - physiology Neurons - metabolism Original Presynaptic Terminals - physiology Synaptic Transmission - physiology Synaptic Vesicles - physiology vesicle transmission synapse hippocampus amyloid beta
Online Access:	Get full text
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