Antineoplastic activity of selected constituents of Duguetia glabriuscula

• Published in: Fitoterapia Vol. 77; no. 3; pp. 227 - 229
• Main Authors: Matos, M.F.C., Leite, L.I.S.P., Brustolim, D., de Siqueira, J.M., Carollo, C.A., Hellmann, A.R., Pereira, N.F.G., da Silva, D.B.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-04-2006; Elsevier
• Subjects: Annonaceae - chemistry; Antineoplastic Agents, Phytogenic - toxicity; Biological and medical sciences; Cell Line, Tumor; Cisplatin - toxicity; Cytotoxicity; Duguetia glabriuscula; General pharmacology; Humans; Inhibitory Concentration 50; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant Extracts - chemistry; Plant Extracts - toxicity; Plant Leaves - chemistry; Polycarpol; Polycyclic Aromatic Hydrocarbons - toxicity; Sesquiterpenes; Sitosterols - toxicity; Toxicity Tests - methods; β-Sitosterol; Cytotoxicity; Polycarpol; β-Sitosterol; Duguetia glabriuscula; Sesquiterpenes; Antineoplastic agent; p-Sitosterol; Pharmacognosy; Plant origin; Medicinal plant
• ISSN: 0367-326X
• DOI: 10.1016/j.fitote.2006.01.013

The cytotoxic effects of seven constituents isolated from
Duguetia glabriuscula were evaluated against Hep
2 human larynx carcinoma cells. The cytotoxicity exhibited by β-sitosterol was as strong as that of
cis-platin. (+)-Alloaromadendran-10,14β-diol caused inhibition of cellular growth with IC
50 values lower than 25 μg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.