MRI-based quantification of cerebral edema in individual SHRSP rats using averaged criteria determined before the occurrence of edema

• Published in: Magnetic resonance imaging Vol. 17; no. 6; pp. 903 - 907
• Main Authors: Blezer, Erwin L.A, Nicolay, Klaas, Viergever, Max A, Koomans, Hein A, Joles, Jaap A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-07-1999; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Brain - pathology; Brain Edema - diagnosis; Cerebral edema; Data Interpretation, Statistical; Hypertension - complications; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical sciences; Nervous system; Quantification; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Rats; SHRSP; Sodium Chloride; Threshold; SHRSP; Quantification; Cerebral edema; Threshold; Animal model; Edema; Nervous system diseases; Stroke; Rat; Threshold detection; Rodentia; Cardiovascular disease; Nuclear magnetic resonance imaging; Cerebral disorder; Vascular disease; Vertebrata; Mammalia; Animal; Central nervous system disease; Parameter; Technique; Cerebrovascular disease; Quantitative analysis; Brain (vertebrata)
• ISSN: 0730-725X; 1873-5894
• DOI: 10.1016/S0730-725X(99)00031-4

This study evaluated whether it is possible with T
2-weighted MRI to quantitatively relate image-outcome in a single, individual case with that of a standardized control group that did not show these pathologies. An animal model of hypertension-related cerebral damage, the salt-loaded, stroke-prone spontaneously hypertensive rat (SHRSP), was applied. Very similar values for cerebral edema were found when using either the individual or the averaged threshold. The values were positively correlated with each, as
edema
averaged threshold
= 0.12 + 0.99 ×
edema
individual threshold
(Pearsons coefficient = 0.99,
p < 0.0001). This line was virtually congruent with the line of identity. Thus, by determination of the averaged threshold in the healthy salt-loaded SHRSP, a parameter was obtained to calculate cerebral edema with the specifically used T
2-weighted MRI protocol, in any rat.