Novel somatic mutations of the VHL gene in an erythropoietin‐producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells

Mutation of the VHL tumor suppressor gene is a frequent genetic event in the carcinogenesis of renal‐cell carcinoma (RCC). Circulating endothelial progenitor cells (EPCs) have important role in neoangiogenesis, and mobilization of these cells is induced by various growth factors including erythropoi...

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Bibliographic Details
Published in:	American journal of hematology Vol. 83; no. 2; pp. 155 - 158
Main Authors:	Rad, Farhad Haghighi, Ulusakarya, Ayhan, Gad, Sophie, Sibony, Mathilde, Juin, Fabrice, Richard, Stéphane, Machover, David, Uzan, Georges
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-02-2008 Wiley-Liss Wiley
Subjects:	Aged Biological and medical sciences Biotechnology Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - complications Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - surgery Computer Science Diseases of red blood cells DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Endothelium, Vascular - pathology Erythropoietin - genetics Hematologic and hematopoietic diseases Humans Kidney Neoplasms - blood Kidney Neoplasms - complications Kidney Neoplasms - genetics Kidney Neoplasms - surgery Kidneys Life Sciences Male Medical sciences Mutation Nephrectomy Nephrology. Urinary tract diseases Polycythemia - blood Polycythemia - complications Polycythemia - genetics Polycythemias Reverse Transcriptase Polymerase Chain Reaction Stem Cells - cytology Stem Cells - pathology Tumors of the urinary system Von Hippel-Lindau Tumor Suppressor Protein - genetics Kidney disease Endothelial cell Secondary Urinary system disease Erythropoietin Hematology Stem cell Hemopathy Malignant tumor Somatic mutation Polypeptide Polycythemia Kidney cancer Cancer Tumor suppressor gene
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