Alloreactivity and apoptosis in graft rejection and transplantation tolerance

Weissmann wrote as early as 1889 that higher organisms contain within themselves the germs of death [1]. However, the term, programmed cell death, or apoptosis as it is now known, was defined much later [2]. Thus, it was long recognized that damaged and old cells are eliminated within the body, but...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 68; no. 2; pp. 167 - 174
Main Authors:	Zavazava, Nicholas, Kabelitz, Dietrich
Format:	Journal Article
Language:	English
Published:	United States Society for Leukocyte Biology 01-08-2000
Subjects:	Animals Apoptosis - immunology Fas/CD95 Fas‐ligand(FasL)/CD95‐L Graft Rejection - immunology Humans Isoantigens - immunology Organ Transplantation peripheral tolerance programmed cell death soluble MHC T-Lymphocytes - immunology Transplantation Immunology
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Summary:	Weissmann wrote as early as 1889 that higher organisms contain within themselves the germs of death [1]. However, the term, programmed cell death, or apoptosis as it is now known, was defined much later [2]. Thus, it was long recognized that damaged and old cells are eliminated within the body, but the underlying mechanisms are only now beginning to emerge. Apoptosis appears central to the process of negative selection of developing T‐cells in the thymus. In regard to organ transplantation, apoptosis contributes to graft rejection and the establishment of graft tolerance. Thus, understanding the regulatory mechanisms of apoptosis may help establish a new protocol for the induction of transplantation tolerance.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0741-5400 1938-3673
DOI:	10.1189/jlb.68.2.167