Epigenetic inactivation of Homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features

Promoter methylation is an important mechanism in gene silencing and is a key epigenetic event in cancer development. Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor suppressor gene in breast cancer, but its role in lung cancer is s...

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Bibliographic Details
Published in:	Molecular carcinogenesis Vol. 48; no. 12; pp. 1109 - 1115
Main Authors:	Kim, Dong-Sun, Kim, Min-Jin, Lee, Ji-Yun, Lee, Su-Man, Choi, Jun-Young, Yoon, Ghil-Suk, Na, Yeon-Kyung, Hong, Hae-Sook, Kim, Sang-Geol, Choi, Jin-Eun, Lee, Shin-Yeop, Park, Jae-Yong
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-12-2009
Subjects:	Adenocarcinoma - genetics Adenocarcinoma - pathology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - secondary DNA Methylation Epigenesis, Genetic Female Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics HOXA5 Humans Immunoenzyme Techniques Lung Neoplasms - genetics Lung Neoplasms - pathology Male methylation Middle Aged Neoplasm Staging NSCLC Prognosis Promoter Regions, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Rate
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