Design, synthesis and evaluation of pyrrolo[2,3-d]pyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors

A series of novel pyrrolo[2,3-d]pyrimidine-phenylamide hybrids were designed using the hybridization strategy and synthesized as potential JAK2 inhibitors. [Display omitted] Janus kinase 2 (JAK2) plays an essential role in the signaling of hormone-like cytokines and growth factors, which has been co...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 26; no. 12; pp. 2936 - 2941
Main Authors:	Wang, Tingfang, Liu, Xiaofei, Hao, Meixi, Qiao, Jianan, Ju, Caoyun, Xue, Lingjing, Zhang, Can
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-06-2016
Subjects:	Amides - administration & dosage Amides - chemistry Amides - pharmacology Animals Cell Line, Tumor Dose-Response Relationship, Drug Drug Design Humans Hybridization JAK2 inhibitors Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Mice Molecular Docking Simulation Molecular Structure Myeloproliferative neoplasms Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Pyrimidines - administration & dosage Pyrimidines - chemistry Pyrimidines - pharmacology Pyrroles - administration & dosage Pyrroles - chemistry Pyrroles - pharmacology Pyrrolo[2,3-d]pyrimidine Rats Rats, Sprague-Dawley Structure-Activity Relationship JAK2 inhibitors Hybridization Pyrrolo[2,3-d]pyrimidine Myeloproliferative neoplasms
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