5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding

A series of alkyl tetrahydrofuran-2-carboxylates ( 1– 4) bearing a new set of three pharmacophoric groups were tested as protein kinase C (PKC) ligands. The compounds were synthesized from commercially available glycidyl 4-methoxyphenyl ether. The correlation between their binding affinities for PKC...

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Published in:	Farmaco (Società chimica italiana : 1989) Vol. 56; no. 3; pp. 203 - 210
Main Authors:	Lee, Jeewoo, Han, Kee-Chung, Lee, Sang-Yoon, Kim, Su-Yeon, Kang, Ji-Hye, Lewin, Nancy E., Best, Lionel S., Blumberg, Peter M., Marquez, Victor E.
Format:	Journal Article
Language:	English
Published:	Lausanne Elsevier SAS 01-03-2001 Elsevier Science
Subjects:	Binding, Competitive Biological and medical sciences Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Diacylglycerol–lactones Furans - chemical synthesis Furans - chemistry Kinetics Ligands Medical sciences Miscellaneous Models, Molecular Molecular Conformation Pharmacology. Drug treatments Pharmacophore model Phorbol 12,13-Dibutyrate Phorbol ester PKC ligands Protein Binding Protein kinase C Protein Kinase C - metabolism Templates, Genetic Protein kinase C Diacylglycerol–lactones Pharmacophore model Phorbol ester PKC ligands Stereoisomer Five membered ring Enzyme Transferases Oxygen heterocycle In vitro Biological activity Primary alcohol Signal transduction Biological fixation Chemical synthesis Acylate
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