Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo

A novel method for the parallel synthesis of peptide-biocargo conjugates was developed that utilizes affinity purification for fast isolation of the conjugates in order to avoid time consuming HPLC purification. The methodology was applied to create two libraries of cell-penetrating peptide (CPP)-PN...

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Bibliographic Details

Published in:	Organic & biomolecular chemistry Vol. 11; no. 43; p. 7621
Main Authors:	Deuss, Peter J, Arzumanov, Andrey A, Williams, Donna L, Gait, Michael J
Format:	Journal Article
Language:	English
Published:	England 21-11-2013
Subjects:	Cell-Penetrating Peptides - chemical synthesis Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - metabolism Chromatography, High Pressure Liquid HeLa Cells Humans Molecular Conformation Peptide Library Peptide Nucleic Acids - chemistry Peptide Nucleic Acids - metabolism RNA Splicing - genetics RNA, Messenger - genetics RNA, Messenger - metabolism
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