PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro

• Published in: European journal of pharmacology Vol. 332; no. 2; pp. 161 - 165
• Main Authors: Huang, Ling-Qian, A. Breakwell, Nicholas, Rowan, Michael J, Roger Anwyl
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 06-08-1997; Elsevier
• Subjects: Alanine - analogs & derivatives; Alanine - pharmacology; Animals; Biological and medical sciences; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Cyclopropanes - pharmacology; Dentate Gyrus - drug effects; Dentate Gyrus - physiology; Evoked Potentials, Somatosensory - drug effects; Fundamental and applied biological sciences. Psychology; Glycine - analogs & derivatives; Glycine - pharmacology; Hippocampus; In Vitro Techniques; Long-term potentiation; Long-Term Potentiation - drug effects; Male; mGlu receptor; MTPG (( R, S)- α-methyl-4-tetrazolylphenylglycine); PCCG-IV ((2 S,1′ S,2′ S,3′ R)-2-(2″-carboxy-3′-phenylcyclopropyl)glycine); Rats; Rats, Wistar; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Tetrazoles - pharmacology; Vertebrates: nervous system and sense organs; MTPG (( R, S)- α-methyl-4-tetrazolylphenylglycine); Long-term potentiation; PCCG-IV ((2 S,1′ S,2′ S,3′ R)-2-(2″-carboxy-3′-phenylcyclopropyl)glycine); mGlu receptor; Hippocampus; Agonist; Rat; Rodentia; Central nervous system; Molecular interaction; Glutamate receptor; In vitro; Mechanism; Vertebrata; Biological fixation; Dentate gyrus; Regulation(control); Mammalia; Structure activity relation; Metabotropic receptor; Animal; Excitatory postsynaptic potential; Subtype; Brain (vertebrata)
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(97)01079-0

The effects of two ligands with previously established high and selective potency for metabotropic glutamate receptors (mGlu receptors) group II have been investigated on the high frequency stimulation (HFS) induced long-term potentiation of the field excitatory postsynaptic potential (EPSP) in the dentate gyrus of the rat hippocampus in vitro. The ligands investigated were (2
S,1′
S,2′
S,3′
R)-2-(2″-carboxy-3′-phenylcyclopropyl)glycine (PCCG-IV) and (
R,
S)-
α-methyl-4-tetrazolylphenylglycine (MTPG). PCCG-IV (10
μM) strongly inhibited the induction of long-term potentiation of the field EPSP by high frequency stimulation. MTPG (50
μM) did not inhibit the induction of long-term potentiation, but prevented the inhibition of long-term potentiation induction by PCCG-IV. The inhibition of long-term potentiation induction by PCCG-IV is suggested to be due to an agonistic action on mGlu receptor group II, probably mGlu
3 receptor, as the inhibition of long-term potentiation can be reversed by the application of MTPG, a well-known selective and potent antagonist of mGlu receptor group II.