Primary and secondary amenorrhea associated with spironolactone therapy in chronic liver disease

Women with severe liver disease often have amenorrhea that resolves as liver disease abates. We describe three patients with mild to moderate chronic liver disease and amenorrhea. In each case amenorrhea resolved when spironolactone therapy was discontinued. We suggest that spironolactone, an androg...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 121; no. 1; p. 141
Main Authors:	Potter, C, Willis, D, Sharp, H L, Scharzenberg, S J
Format:	Journal Article
Language:	English
Published:	United States 01-07-1992
Subjects:	Adolescent Adult Amenorrhea - chemically induced Amenorrhea - etiology Cholestasis - complications Chronic Disease Female Humans Hypertension, Portal - complications Hypogonadism - complications Liver Cirrhosis - complications Liver Diseases - complications Liver Diseases - drug therapy Lymphedema - complications Spironolactone - adverse effects Spironolactone - therapeutic use Syndrome
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Summary:	Women with severe liver disease often have amenorrhea that resolves as liver disease abates. We describe three patients with mild to moderate chronic liver disease and amenorrhea. In each case amenorrhea resolved when spironolactone therapy was discontinued. We suggest that spironolactone, an androgen inhibitor, may also cause reversible amenorrhea.
ISSN:	0022-3476
DOI:	10.1016/S0022-3476(05)82562-4