Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies
In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious ( p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and...
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| Published in: | The Journal of pediatrics Vol. 128; no. 4; pp. 573 - 576 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Mosby, Inc
01-04-1996
Elsevier |
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| Abstract | In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (
p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose. (J P
EDIATR 1996;128:573-6) |
|---|---|
| AbstractList | In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (
p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose. (J P
EDIATR 1996;128:573-6) In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose. |
| Author | Slovis, Thomas L. McCarver-May, D.Gail Aouthmany, Moustafa Kang, Jun Elton, Rhonda Kauffman, Ralph Mowery, Joy L. |
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| Cites_doi | 10.2214/ajr.161.3.8352124 10.1148/radiology.175.3.2343104 10.1542/peds.89.6.1110 10.2214/ajr.150.2.377 10.1097/00004728-199201000-00002 10.1016/S0022-3476(05)82066-9 10.1007/BF02026712 10.3928/0191-3913-19900901-06 10.1007/BF00169294 10.1097/00004728-199105000-00023 |
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| Copyright | 1996 Mosby, Inc. 1996 INIST-CNRS |
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| Keywords | MAP Sa O 2 Human Toxicity Central nervous system General anesthesia Hypnotic Chemotherapy Newborn General anesthetic Efficiency Benzodiazepine derivatives Medical imagery Sedative Comparative study |
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| References | Greenberg, Faerber, Aspinall (bib7) 1991; 15 Fox, O'Brien, Kangas, Murphree, Wright (bib8) 1990; 27 Tolia, Brennan, Aravind, Kauffman (bib2) 1991; 119 Wolffgramm, Mikolaiczyk, Coper (bib4) 1994; 349 Hartwig, Roth, Theisohn (bib5) 1991; 150 Greenberg, Faerber, Aspinall, Adams (bib1) 1993; 161 American Academy of Pediatrics Committee on Drugs (bib10) 1992; 89 Hubbard, Markowitz, Kimmel, Kroger, Bartko (bib6) 1992; 16 Diament, Stanley (bib3) 1988; 150 Fisher (bib9) 1990; 175 8969746 - J Pediatr. 1996 Dec;129(6):944-5 Tolia (10.1016/S0022-3476(96)70375-X_bib2) 1991; 119 Greenberg (10.1016/S0022-3476(96)70375-X_bib7) 1991; 15 Hubbard (10.1016/S0022-3476(96)70375-X_bib6) 1992; 16 American Academy of Pediatrics Committee on Drugs (10.1016/S0022-3476(96)70375-X_bib10) 1992; 89 Diament (10.1016/S0022-3476(96)70375-X_bib3) 1988; 150 Greenberg (10.1016/S0022-3476(96)70375-X_bib1) 1993; 161 Fisher (10.1016/S0022-3476(96)70375-X_bib9) 1990; 175 Wolffgramm (10.1016/S0022-3476(96)70375-X_bib4) 1994; 349 Fox (10.1016/S0022-3476(96)70375-X_bib8) 1990; 27 Hartwig (10.1016/S0022-3476(96)70375-X_bib5) 1991; 150 |
| References_xml | – volume: 175 start-page: 613 year: 1990 end-page: 615 ident: bib9 article-title: Sedation of pediatric patients: an anesthesiologist's perspective publication-title: Radiology contributor: fullname: Fisher – volume: 27 start-page: 242 year: 1990 end-page: 244 ident: bib8 article-title: Use of high dose chloral hydrate for ophthalmic exams in children: a retrospective review of 302 cases publication-title: J Pediatr Ophthalmol Strabismus contributor: fullname: Wright – volume: 161 start-page: 639 year: 1993 end-page: 641 ident: bib1 article-title: High dose chloral hydrate sedation for children undergoing MR imaging: safety and efficacy in relation to age publication-title: AJR Am J Roentgenol contributor: fullname: Adams – volume: 16 start-page: 3 year: 1992 end-page: 6 ident: bib6 article-title: Sedation for pediatric patients undergoing CT and MRI publication-title: J Comput Assist Tomogr contributor: fullname: Bartko – volume: 119 start-page: 467 year: 1991 end-page: 471 ident: bib2 article-title: Pharmacokinetic and pharmacodynamic study of midazolam in children during esophagogastroduodenoscopy publication-title: J Pediatr contributor: fullname: Kauffman – volume: 89 start-page: 1110 year: 1992 end-page: 1115 ident: bib10 article-title: Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic, dental, and therapeutic procedures publication-title: Pediatrics contributor: fullname: American Academy of Pediatrics Committee on Drugs – volume: 349 start-page: 279 year: 1994 end-page: 286 ident: bib4 article-title: Acute and subchronic benzodiazepine-barbiturate-interactions on behaviour and physiological responses of the mouse publication-title: Naunyn Schmiedebergs Arch Pharmacol contributor: fullname: Coper – volume: 150 start-page: 784 year: 1991 end-page: 788 ident: bib5 article-title: Clinical experience with continuous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit publication-title: Eur J Pediatr contributor: fullname: Theisohn – volume: 150 start-page: 377 year: 1988 end-page: 378 ident: bib3 article-title: The use of midazolam for sedation of infants and children publication-title: AJR Am J Roentgenol contributor: fullname: Stanley – volume: 15 start-page: 467 year: 1991 end-page: 469 ident: bib7 article-title: High dose chloral hydrate sedation for children undergoing CT publication-title: J Comput Assist Tomogr contributor: fullname: Aspinall – volume: 161 start-page: 639 year: 1993 ident: 10.1016/S0022-3476(96)70375-X_bib1 article-title: High dose chloral hydrate sedation for children undergoing MR imaging: safety and efficacy in relation to age publication-title: AJR Am J Roentgenol doi: 10.2214/ajr.161.3.8352124 contributor: fullname: Greenberg – volume: 175 start-page: 613 year: 1990 ident: 10.1016/S0022-3476(96)70375-X_bib9 article-title: Sedation of pediatric patients: an anesthesiologist's perspective publication-title: Radiology doi: 10.1148/radiology.175.3.2343104 contributor: fullname: Fisher – volume: 89 start-page: 1110 year: 1992 ident: 10.1016/S0022-3476(96)70375-X_bib10 article-title: Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic, dental, and therapeutic procedures publication-title: Pediatrics doi: 10.1542/peds.89.6.1110 contributor: fullname: American Academy of Pediatrics Committee on Drugs – volume: 150 start-page: 377 year: 1988 ident: 10.1016/S0022-3476(96)70375-X_bib3 article-title: The use of midazolam for sedation of infants and children publication-title: AJR Am J Roentgenol doi: 10.2214/ajr.150.2.377 contributor: fullname: Diament – volume: 16 start-page: 3 year: 1992 ident: 10.1016/S0022-3476(96)70375-X_bib6 article-title: Sedation for pediatric patients undergoing CT and MRI publication-title: J Comput Assist Tomogr doi: 10.1097/00004728-199201000-00002 contributor: fullname: Hubbard – volume: 119 start-page: 467 year: 1991 ident: 10.1016/S0022-3476(96)70375-X_bib2 article-title: Pharmacokinetic and pharmacodynamic study of midazolam in children during esophagogastroduodenoscopy publication-title: J Pediatr doi: 10.1016/S0022-3476(05)82066-9 contributor: fullname: Tolia – volume: 150 start-page: 784 year: 1991 ident: 10.1016/S0022-3476(96)70375-X_bib5 article-title: Clinical experience with continuous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit publication-title: Eur J Pediatr doi: 10.1007/BF02026712 contributor: fullname: Hartwig – volume: 27 start-page: 242 year: 1990 ident: 10.1016/S0022-3476(96)70375-X_bib8 article-title: Use of high dose chloral hydrate for ophthalmic exams in children: a retrospective review of 302 cases publication-title: J Pediatr Ophthalmol Strabismus doi: 10.3928/0191-3913-19900901-06 contributor: fullname: Fox – volume: 349 start-page: 279 year: 1994 ident: 10.1016/S0022-3476(96)70375-X_bib4 article-title: Acute and subchronic benzodiazepine-barbiturate-interactions on behaviour and physiological responses of the mouse publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/BF00169294 contributor: fullname: Wolffgramm – volume: 15 start-page: 467 year: 1991 ident: 10.1016/S0022-3476(96)70375-X_bib7 article-title: High dose chloral hydrate sedation for children undergoing CT publication-title: J Comput Assist Tomogr doi: 10.1097/00004728-199105000-00023 contributor: fullname: Greenberg |
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| Snippet | In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (
p<0.05) but... In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but... |
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| SubjectTerms | Biological and medical sciences Chloral Hydrate - pharmacology Conscious Sedation Cross-Over Studies Humans Hypnotics and Sedatives - pharmacology Hypnotics. Sedatives Infant, Newborn Medical sciences Midazolam - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed |
| Title | Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies |
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