Psammaplysin F: A unique inhibitor of bacterial chromosomal partitioning
Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant...
Saved in:
| Published in: | Bioorganic & medicinal chemistry letters Vol. 23; no. 17; pp. 4862 - 4866 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01-09-2013
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40–80μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. |
|---|---|
| AbstractList | Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 mu M, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80 mu M) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. |
| Author | Whitchurch, Cynthia B. Amirul Islam, Md Ramsey, Deborah M. Turnbull, Lynne McAlpine, Shelli R. Davis, Rohan A. |
| Author_xml | – sequence: 1 givenname: Deborah M. surname: Ramsey fullname: Ramsey, Deborah M. organization: Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia – sequence: 2 givenname: Md surname: Amirul Islam fullname: Amirul Islam, Md organization: Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia – sequence: 3 givenname: Lynne surname: Turnbull fullname: Turnbull, Lynne organization: The ithree institute,University of Technology, Sydney, Ultimo, NSW 2007, Australia – sequence: 4 givenname: Rohan A. surname: Davis fullname: Davis, Rohan A. organization: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia – sequence: 5 givenname: Cynthia B. surname: Whitchurch fullname: Whitchurch, Cynthia B. organization: The ithree institute,University of Technology, Sydney, Ultimo, NSW 2007, Australia – sequence: 6 givenname: Shelli R. surname: McAlpine fullname: McAlpine, Shelli R. email: s.mcalpine@unsw.edu.au organization: Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23891184$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkD1PwzAQhi0EglL4AwwoI0vC2bHTBLGgii-pEgwgsVm2cwFXiV3sFIl_j6sCI0x3w3Pv3T2HZNd5h4ScUCgo0Op8WejB9AUDWhZQFVCzHTKhvOJ5yUHskgk0FeR1w18OyGGMSwDKgfN9csDKuqG05hNy9xjVMKhV_xmty24usqts7ez7GjPr3qy2ow-Z7zKtzIjBqj4zb8EPPvoh9SsVRjta76x7PSJ7neojHn_XKXm-uX6a3-WLh9v7-dUiN2nnmKsaEJg2VKgSW16pBrtGM83MLLVCoG5BiBmg0RyNmHXc6BYb1nYVbSnW5ZScbXNXwacz4ygHGw32vXLo11FSwaBs0qfif5TTpuQ00QllW9QEH2PATq6CHVT4lBTkRrZcyo1suZEtoZJJdho6_c5f6wHb35Efuwm43AKYhHxYDDIai85gawOaUbbe_pX_BUMpkvQ |
| CitedBy_id | crossref_primary_10_1016_j_biocel_2019_04_008 crossref_primary_10_1039_C6NP00067C crossref_primary_10_3390_md19080433 crossref_primary_10_1021_jacs_2c10010 crossref_primary_10_3390_biom9120841 crossref_primary_10_3390_md20110663 crossref_primary_10_1002_cbdv_202400962 |
| Cites_doi | 10.1128/AEM.62.12.4521-4528.1996 10.1021/bi300645n 10.1073/pnas.092142499 10.1039/C2MD20127E 10.1099/jmm.0.46319-0 10.4161/viru.1.5.12983 10.1081/ABIO-120005771 10.1038/srep01116 10.1051/vetres:2001123 10.1074/jbc.M307625200 10.1016/j.bmcl.2010.11.081 10.1128/JB.00010-10 10.1021/np50084a021 10.1001/jama.2009.1754 10.1111/j.1742-4658.2010.07780.x 10.1038/nrd2510 10.1021/np300560b 10.1101/gad.12.9.1254 10.1038/ja.2013.14 10.1021/np970070s 10.1002/anie.201007298 10.1021/np900834g 10.1073/pnas.082188899 10.1007/BF02976431 10.1128/JB.180.15.3946-3953.1998 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ltd Copyright © 2013 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2013 Elsevier Ltd – notice: Copyright © 2013 Elsevier Ltd. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7QL 7QO 7T7 8FD C1K FR3 P64 RC3 |
| DOI | 10.1016/j.bmcl.2013.06.082 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Genetics Abstracts Biotechnology Research Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | Genetics Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology Chemistry |
| EISSN | 1464-3405 |
| EndPage | 4866 |
| ExternalDocumentID | 10_1016_j_bmcl_2013_06_082 23891184 S0960894X13008159 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: NIH 1R01CA137873 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATCM AAXUO ABBQC ABFNM ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADECG ADEZE ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 D0L DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM LCYCR LZ2 M29 M2Z M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPC SPCBC SSH SSK SSP SSU SSZ T5K YK3 ZMT ~02 ~G- AAXKI AKRWK CGR CUY CVF ECM EIF NPM .HR 53G 6TJ AAQXK AAYXX ABTAH ACNNM ADMUD AFFNX AFJKZ AGRDE ASPBG AVWKF AZFZN CITATION FEDTE FGOYB G-2 HEA HMK HMO HMS HMT HVGLF HZ~ R2- SAE SCB SEW SOC SPT WUQ XPP Y6R ZY4 7X8 7QL 7QO 7T7 8FD C1K FR3 P64 RC3 |
| ID | FETCH-LOGICAL-c389t-a80e02bc15a3ed46a9ef9b2b2c7a9e55ebd05570ecb4ec57f4cbde92df61d1e83 |
| ISSN | 0960-894X |
| IngestDate | Sat Oct 05 06:09:32 EDT 2024 Sat Oct 05 04:52:41 EDT 2024 Thu Sep 26 16:02:06 EDT 2024 Sat Sep 28 07:54:32 EDT 2024 Fri Feb 23 02:17:11 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 17 |
| Keywords | Cell division Amine Antibiotics Natural products DNA |
| Language | English |
| License | Copyright © 2013 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c389t-a80e02bc15a3ed46a9ef9b2b2c7a9e55ebd05570ecb4ec57f4cbde92df61d1e83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 23891184 |
| PQID | 1419341390 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1520390145 proquest_miscellaneous_1419341390 crossref_primary_10_1016_j_bmcl_2013_06_082 pubmed_primary_23891184 elsevier_sciencedirect_doi_10_1016_j_bmcl_2013_06_082 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-09-01 2013-Sep-01 2013-09-00 20130901 |
| PublicationDateYYYYMMDD | 2013-09-01 |
| PublicationDate_xml | – month: 09 year: 2013 text: 2013-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Bioorganic & medicinal chemistry letters |
| PublicationTitleAlternate | Bioorg Med Chem Lett |
| PublicationYear | 2013 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Soufo, Graumann (b0155) 1916; 2003 Fan, Butler, Riss, Wood (b0100) 2004 Mcdermott, Zhao, Wagner, Simjee, Walker, White (b0010) 2002; 13 Vincent, Rello, Marshall, Silva, Anzueto, Martin, Moreno, Lipman, Gomersall, Sakr, Reinhart (b0020) 2009; 302 Yang, Davis, Buchanan, Duffy, Avery, Camp, Quinn (b0090) 2010; 73 Anderson, Kim, Moore, O’Brien, Sorto, Grove, Lackner, Ames, Shaw (b0050) 1918; 2012 Copp, Ireland, Barrows (b0085) 1992; 55 Trusca, Scott, Thompson, Bramhill (b0140) 1998; 180 Skold (b0030) 2001; 32 Pick, Rawat, Arad, Lan, Fan, Kende, Av-Gay (b0110) 2006; 55 Fan, Butler, Riss, Wood (b0095) 2005 Liu, Fu, Schmitz, Kelly-Borges (b0075) 1997; 60 Drusano (b0025) 2010; 65 Koralegedara, Aw, Burns (b0130) 1930; 2011 Foss, Eun, Grove, Pauw, Sorto, Rensvold, Pagliarini, Shaw, Weibel (b0160) 2013; 4 Lipsitch, Singer, Levin (b0005) 2002; 99 Mudianta, Skinner-Adams, Andrews, Davis, Hadi, Hayes, Garson (b0080) 2012; 75 Dale, Hinds, Mann, Taylor, Neidle (b0135) 2012; 51 Yu, Herbert, Graumann, Gotz (b0150) 2010; 192 Heissenberger, Leppard, Herndl (b0115) 1996; 62 Britton, Lin, Grossman (b0145) 1998; 12 Kim, Lee, Jung, Yang (b0105) 1999; 22 Dan, Lei, Yao, Wang, Winterhalder, Zumbusch, Qi, Xia, Yan, Yang, Gao, Ye, Zhao (b0120) 2013; 3 Smith, Harris, johnson, Silbergeld, Morris (b0015) 2002; 99 Xu, Andrews, Birrell, Tran, Camp, Davis, Quinn (b0070) 2011; 21 Chen, Koripella, Sanyal, Selmer (b0040) 2010; 277 Wang, Galgoci, Kodali, Herath, Jayasuriya, Dorso, Vicente, Gonzalez, Cully, Bramhill, Singh (b0060) 2003; 278 Shigemura, Osawa, Mukai, Yoshida, Fujisawa, Arakawa (b0035) 2013; 66 Park, Grove, Gonzalez-Lopez, Urgaonkar, Fettinger, Shaw (b0055) 2011; 50 Wiesner, Vilcinskas (b0125) 2010; 1 Queensland compound library. Http://www.griffith.edu.au/science-aviation/queensland-compound-library. Lock, Harry (b0045) 2008; 7 Pick (10.1016/j.bmcl.2013.06.082_b0110) 2006; 55 Fan (10.1016/j.bmcl.2013.06.082_b0100) 2004 Drusano (10.1016/j.bmcl.2013.06.082_b0025) 2010; 65 Dale (10.1016/j.bmcl.2013.06.082_b0135) 2012; 51 Lipsitch (10.1016/j.bmcl.2013.06.082_b0005) 2002; 99 10.1016/j.bmcl.2013.06.082_b0065 Copp (10.1016/j.bmcl.2013.06.082_b0085) 1992; 55 Foss (10.1016/j.bmcl.2013.06.082_b0160) 2013; 4 Kim (10.1016/j.bmcl.2013.06.082_b0105) 1999; 22 Wang (10.1016/j.bmcl.2013.06.082_b0060) 2003; 278 Heissenberger (10.1016/j.bmcl.2013.06.082_b0115) 1996; 62 Vincent (10.1016/j.bmcl.2013.06.082_b0020) 2009; 302 Chen (10.1016/j.bmcl.2013.06.082_b0040) 2010; 277 Fan (10.1016/j.bmcl.2013.06.082_b0095) 2005 Mcdermott (10.1016/j.bmcl.2013.06.082_b0010) 2002; 13 Xu (10.1016/j.bmcl.2013.06.082_b0070) 2011; 21 Trusca (10.1016/j.bmcl.2013.06.082_b0140) 1998; 180 Mudianta (10.1016/j.bmcl.2013.06.082_b0080) 2012; 75 Dan (10.1016/j.bmcl.2013.06.082_b0120) 2013; 3 Koralegedara (10.1016/j.bmcl.2013.06.082_b0130) 1930; 2011 Shigemura (10.1016/j.bmcl.2013.06.082_b0035) 2013; 66 Skold (10.1016/j.bmcl.2013.06.082_b0030) 2001; 32 Soufo (10.1016/j.bmcl.2013.06.082_b0155) 1916; 2003 Britton (10.1016/j.bmcl.2013.06.082_b0145) 1998; 12 Yu (10.1016/j.bmcl.2013.06.082_b0150) 2010; 192 Yang (10.1016/j.bmcl.2013.06.082_b0090) 2010; 73 Wiesner (10.1016/j.bmcl.2013.06.082_b0125) 2010; 1 Smith (10.1016/j.bmcl.2013.06.082_b0015) 2002; 99 Park (10.1016/j.bmcl.2013.06.082_b0055) 2011; 50 Lock (10.1016/j.bmcl.2013.06.082_b0045) 2008; 7 Anderson (10.1016/j.bmcl.2013.06.082_b0050) 1918; 2012 Liu (10.1016/j.bmcl.2013.06.082_b0075) 1997; 60 |
| References_xml | – volume: 2011 start-page: 76 year: 1930 ident: b0130 publication-title: J. Org. Chem. contributor: fullname: Burns – volume: 7 start-page: 324 year: 2008 ident: b0045 publication-title: J. Nat. Rev. Drug Disc. contributor: fullname: Harry – volume: 73 start-page: 985 year: 2010 ident: b0090 publication-title: J. Nat. Prod. contributor: fullname: Quinn – volume: 302 start-page: 2323 year: 2009 ident: b0020 publication-title: J. Am. Med. Assoc. contributor: fullname: Reinhart – volume: 50 start-page: 3730 year: 2011 ident: b0055 publication-title: Angew. Chem. Int. Ed. contributor: fullname: Shaw – start-page: 2 year: 2004 end-page: 4 ident: b0100 publication-title: Promega Notes contributor: fullname: Wood – volume: 65 start-page: iv33 year: 2010 ident: b0025 publication-title: Antimicrob. Agents Chemother. contributor: fullname: Drusano – volume: 75 start-page: 2132 year: 2012 ident: b0080 publication-title: J. Nat. Prod. contributor: fullname: Garson – volume: 192 start-page: 4067 year: 2010 ident: b0150 publication-title: J. Bacteriol. contributor: fullname: Gotz – volume: 3 start-page: 1116 year: 2013 ident: b0120 publication-title: Sci. Rep. contributor: fullname: Zhao – volume: 4 start-page: 112 year: 2013 ident: b0160 publication-title: Med. Chem. Commun. contributor: fullname: Weibel – volume: 12 start-page: 1254 year: 1998 ident: b0145 publication-title: Gene Dev. contributor: fullname: Grossman – volume: 1 start-page: 440 year: 2010 ident: b0125 publication-title: Virulence contributor: fullname: Vilcinskas – volume: 2003 start-page: 13 year: 1916 ident: b0155 publication-title: Curr. Biol. contributor: fullname: Graumann – volume: 99 start-page: 5752 year: 2002 ident: b0005 publication-title: Proc. Natl. Acad. Sci. U.S.A. contributor: fullname: Levin – start-page: 25 year: 2005 end-page: 27 ident: b0095 publication-title: Promega Notes contributor: fullname: Wood – volume: 66 start-page: 273 year: 2013 ident: b0035 publication-title: J. Antibiot. contributor: fullname: Arakawa – volume: 60 start-page: 614 year: 1997 ident: b0075 publication-title: J. Nat. Prod. contributor: fullname: Kelly-Borges – volume: 13 start-page: 71 year: 2002 ident: b0010 publication-title: Anim. Biotechnol. contributor: fullname: White – volume: 99 start-page: 6434 year: 2002 ident: b0015 publication-title: Proc. Natl. Acad. Sci. U.S.A. contributor: fullname: Morris – volume: 51 start-page: 5860 year: 2012 ident: b0135 publication-title: Biochemistry contributor: fullname: Neidle – volume: 22 start-page: 25 year: 1999 ident: b0105 publication-title: Arc. Pharmacol. Res. contributor: fullname: Yang – volume: 55 start-page: 407 year: 2006 ident: b0110 publication-title: J. Med. Microbiol. contributor: fullname: Av-Gay – volume: 55 start-page: 822 year: 1992 ident: b0085 publication-title: J. Nat. Prod. contributor: fullname: Barrows – volume: 180 start-page: 3946 year: 1998 ident: b0140 publication-title: J. Bacteriol. contributor: fullname: Bramhill – volume: 21 start-page: 846 year: 2011 ident: b0070 publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Quinn – volume: 2012 start-page: 7 year: 1918 ident: b0050 publication-title: ACS Chem. Biol. contributor: fullname: Shaw – volume: 278 start-page: 44424 year: 2003 ident: b0060 publication-title: J. Biol. Chem. contributor: fullname: Singh – volume: 62 start-page: 4521 year: 1996 ident: b0115 publication-title: Appl. Environ. Microbiol. contributor: fullname: Herndl – volume: 32 start-page: 261 year: 2001 ident: b0030 publication-title: Vet. Res. contributor: fullname: Skold – volume: 277 start-page: 3789 year: 2010 ident: b0040 publication-title: FEBS J. contributor: fullname: Selmer – volume: 65 start-page: iv33 year: 2010 ident: 10.1016/j.bmcl.2013.06.082_b0025 publication-title: Antimicrob. Agents Chemother. contributor: fullname: Drusano – start-page: 25 year: 2005 ident: 10.1016/j.bmcl.2013.06.082_b0095 publication-title: Promega Notes contributor: fullname: Fan – volume: 62 start-page: 4521 year: 1996 ident: 10.1016/j.bmcl.2013.06.082_b0115 publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.62.12.4521-4528.1996 contributor: fullname: Heissenberger – volume: 51 start-page: 5860 year: 2012 ident: 10.1016/j.bmcl.2013.06.082_b0135 publication-title: Biochemistry doi: 10.1021/bi300645n contributor: fullname: Dale – volume: 99 start-page: 5752 year: 2002 ident: 10.1016/j.bmcl.2013.06.082_b0005 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.092142499 contributor: fullname: Lipsitch – volume: 2011 start-page: 76 year: 1930 ident: 10.1016/j.bmcl.2013.06.082_b0130 publication-title: J. Org. Chem. contributor: fullname: Koralegedara – volume: 4 start-page: 112 year: 2013 ident: 10.1016/j.bmcl.2013.06.082_b0160 publication-title: Med. Chem. Commun. doi: 10.1039/C2MD20127E contributor: fullname: Foss – volume: 55 start-page: 407 year: 2006 ident: 10.1016/j.bmcl.2013.06.082_b0110 publication-title: J. Med. Microbiol. doi: 10.1099/jmm.0.46319-0 contributor: fullname: Pick – volume: 1 start-page: 440 year: 2010 ident: 10.1016/j.bmcl.2013.06.082_b0125 publication-title: Virulence doi: 10.4161/viru.1.5.12983 contributor: fullname: Wiesner – volume: 13 start-page: 71 year: 2002 ident: 10.1016/j.bmcl.2013.06.082_b0010 publication-title: Anim. Biotechnol. doi: 10.1081/ABIO-120005771 contributor: fullname: Mcdermott – volume: 3 start-page: 1116 year: 2013 ident: 10.1016/j.bmcl.2013.06.082_b0120 publication-title: Sci. Rep. doi: 10.1038/srep01116 contributor: fullname: Dan – volume: 32 start-page: 261 year: 2001 ident: 10.1016/j.bmcl.2013.06.082_b0030 publication-title: Vet. Res. doi: 10.1051/vetres:2001123 contributor: fullname: Skold – volume: 278 start-page: 44424 year: 2003 ident: 10.1016/j.bmcl.2013.06.082_b0060 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M307625200 contributor: fullname: Wang – volume: 21 start-page: 846 year: 2011 ident: 10.1016/j.bmcl.2013.06.082_b0070 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2010.11.081 contributor: fullname: Xu – volume: 192 start-page: 4067 year: 2010 ident: 10.1016/j.bmcl.2013.06.082_b0150 publication-title: J. Bacteriol. doi: 10.1128/JB.00010-10 contributor: fullname: Yu – volume: 2003 start-page: 13 year: 1916 ident: 10.1016/j.bmcl.2013.06.082_b0155 publication-title: Curr. Biol. contributor: fullname: Soufo – volume: 55 start-page: 822 year: 1992 ident: 10.1016/j.bmcl.2013.06.082_b0085 publication-title: J. Nat. Prod. doi: 10.1021/np50084a021 contributor: fullname: Copp – start-page: 2 year: 2004 ident: 10.1016/j.bmcl.2013.06.082_b0100 publication-title: Promega Notes contributor: fullname: Fan – volume: 302 start-page: 2323 year: 2009 ident: 10.1016/j.bmcl.2013.06.082_b0020 publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2009.1754 contributor: fullname: Vincent – volume: 2012 start-page: 7 year: 1918 ident: 10.1016/j.bmcl.2013.06.082_b0050 publication-title: ACS Chem. Biol. contributor: fullname: Anderson – volume: 277 start-page: 3789 year: 2010 ident: 10.1016/j.bmcl.2013.06.082_b0040 publication-title: FEBS J. doi: 10.1111/j.1742-4658.2010.07780.x contributor: fullname: Chen – volume: 7 start-page: 324 year: 2008 ident: 10.1016/j.bmcl.2013.06.082_b0045 publication-title: J. Nat. Rev. Drug Disc. doi: 10.1038/nrd2510 contributor: fullname: Lock – volume: 75 start-page: 2132 year: 2012 ident: 10.1016/j.bmcl.2013.06.082_b0080 publication-title: J. Nat. Prod. doi: 10.1021/np300560b contributor: fullname: Mudianta – volume: 12 start-page: 1254 year: 1998 ident: 10.1016/j.bmcl.2013.06.082_b0145 publication-title: Gene Dev. doi: 10.1101/gad.12.9.1254 contributor: fullname: Britton – volume: 66 start-page: 273 year: 2013 ident: 10.1016/j.bmcl.2013.06.082_b0035 publication-title: J. Antibiot. doi: 10.1038/ja.2013.14 contributor: fullname: Shigemura – volume: 60 start-page: 614 year: 1997 ident: 10.1016/j.bmcl.2013.06.082_b0075 publication-title: J. Nat. Prod. doi: 10.1021/np970070s contributor: fullname: Liu – volume: 50 start-page: 3730 year: 2011 ident: 10.1016/j.bmcl.2013.06.082_b0055 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201007298 contributor: fullname: Park – volume: 73 start-page: 985 year: 2010 ident: 10.1016/j.bmcl.2013.06.082_b0090 publication-title: J. Nat. Prod. doi: 10.1021/np900834g contributor: fullname: Yang – volume: 99 start-page: 6434 year: 2002 ident: 10.1016/j.bmcl.2013.06.082_b0015 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.082188899 contributor: fullname: Smith – ident: 10.1016/j.bmcl.2013.06.082_b0065 – volume: 22 start-page: 25 year: 1999 ident: 10.1016/j.bmcl.2013.06.082_b0105 publication-title: Arc. Pharmacol. Res. doi: 10.1007/BF02976431 contributor: fullname: Kim – volume: 180 start-page: 3946 year: 1998 ident: 10.1016/j.bmcl.2013.06.082_b0140 publication-title: J. Bacteriol. doi: 10.1128/JB.180.15.3946-3953.1998 contributor: fullname: Trusca |
| SSID | ssj0014044 |
| Score | 2.1662412 |
| Snippet | Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and... Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and... Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 mu M, and... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 4862 |
| SubjectTerms | Amine Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Cell division Chromosomes, Bacterial - metabolism DNA DNA, Bacterial - metabolism Humans Methicillin-Resistant Staphylococcus aureus - cytology Methicillin-Resistant Staphylococcus aureus - drug effects Natural products Porifera - chemistry Spiro Compounds - chemistry Spiro Compounds - pharmacology Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - pharmacology |
| Title | Psammaplysin F: A unique inhibitor of bacterial chromosomal partitioning |
| URI | https://dx.doi.org/10.1016/j.bmcl.2013.06.082 https://www.ncbi.nlm.nih.gov/pubmed/23891184 https://search.proquest.com/docview/1419341390 https://search.proquest.com/docview/1520390145 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe6TQJeEHQwypeMhHipUjmJkzq8VaNVQRQhNqS9RXbiqJ2WZGqbh_33nD_iBMQmQOIlSqMmdX2_nM93v7tD6G0iYB3hhHg0IIVHQcQeE0x6POSwHIRxHkcqG3l5Nv1ywT7M6XwwaDtUddf-q6ThGshaZc7-hbTdQ-ECnIPM4QhSh-Mfyf3rjpclv1aVRqrxwiSeN6ZK66ZabwS8wTowIEyZZlUeZK0oebu6VElZ6onWR_tTvHdTm_5PmcaKjcjrm23DuPGVTgzqqPO8tDEpq9LGq4lDV7nZNldjB8dV3tE8tpVoTCjk803VxfxdNYRv9RpU0mzSd1eo1hFJ313h8mg60pJ2RsbEY4nhak6kUcU0pl5ISdTX1SY3ucXktKd5KbNaXbYf49-uEMZZcTkRZaYiT36oy7eyoFsPHUvxTA1LjUqF_BjYfQfoKAB9Bur0aPZxfvHJhaso0V2D3d-w2VmGSPjrL91mAd22w9GWzvkj9NBuUfDMYOsxGshqiI5nFd_X5Q1-hzVpWEdjhuj-aSv_Ibq3sjyNY7TsoxAv3uMZNhjEDoO4LrDDIO5hEPcx-AR9X8zPT5ee7dnhZWD67j3OiCSByEABhDKnMU9kAfpABNkUTqNIilxXfZOZoDKLpgXNRC6TIC9iP_clC5-iw6qu5DOEQw62Lw94LgijIuEJExHYw74soiKbUjlC43Ye02tTmiVtOYuXqZr1VM16qoibLBihqJ3q1BqXxmhMARl33vemlUsK86nCabySdbODTTNsfsAGTMgd34kCoryKNBqhEyNUN9ZAUQR8Rp__48heoAfdC_YSHe63jXyFDnZ589ri8wdwKLyP |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Psammaplysin+F%3A+A+unique+inhibitor+of+bacterial+chromosomal+partitioning&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.au=Ramsey%2C+Deborah+M.&rft.au=Amirul+Islam%2C+Md&rft.au=Turnbull%2C+Lynne&rft.au=Davis%2C+Rohan+A.&rft.date=2013-09-01&rft.pub=Elsevier+Ltd&rft.issn=0960-894X&rft.eissn=1464-3405&rft.volume=23&rft.issue=17&rft.spage=4862&rft.epage=4866&rft_id=info:doi/10.1016%2Fj.bmcl.2013.06.082&rft.externalDocID=S0960894X13008159 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-894X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-894X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-894X&client=summon |