Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency

Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency

In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechani...

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Bibliographic Details
Published in:The Journal of pediatrics Vol. 123; no. 1; p. 96
Main Authors: Mayatepek, E, Hoffmann, G F, Bremer, H J
Format: Journal Article
Language:English
Published: United States 01-07-1993
Subjects:
Child
Child, Preschool
Chromatography, High Pressure Liquid
Female
Gas Chromatography-Mass Spectrometry
Humans
Leukotriene E4
Male
Mevalonic Acid - urine
Phosphotransferases (Alcohol Group Acceptor)
Phosphotransferases - deficiency
SRS-A - analogs & derivatives
SRS-A - urine
Urine - cytology
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Summary:In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.
ISSN:0022-3476
DOI:10.1016/S0022-3476(05)81548-3