Dual role of GTP-binding proteins in the control of endothelial prostacyclin

Pretreatment of bovine aortic endothelial cells with pertussis toxin inhibited partially the accumulation of inositol phosphates in response to ATP, whereas cholera toxin had no effect. Both pertussis and cholera toxins enhanced the stimulatory effect of ATP on prostacyclin release from the same cel...

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Bibliographic Details

Published in:	Biochemical and biophysical research communications Vol. 147; no. 3; p. 1113
Main Authors:	Pirotton, S, Erneux, C, Boeynaems, J M
Format:	Journal Article
Language:	English
Published:	United States 30-09-1987
Subjects:	Adenosine Triphosphate - pharmacology Aluminum - pharmacology Aluminum Compounds Calcimycin - pharmacology Cholera Toxin - pharmacology Endothelium, Vascular - physiology Epoprostenol - metabolism Fluorides - pharmacology GTP-Binding Proteins - metabolism Inositol Phosphates - metabolism Pertussis Toxin Sugar Phosphates - metabolism Virulence Factors, Bordetella - pharmacology
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