Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system
The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity of sensitivity...
Saved in:
| Published in: | Journal of Chromatography A Vol. 771; no. 1; pp. 119 - 125 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article Conference Proceeding |
| Language: | English |
| Published: |
Amsterdam
Elsevier B.V
30-05-1997
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity of sensitivity of LC-MS-MS to quantitate trace level components within complex matrices, in particular human plasma. One assay undergoes a validation procedure and demonstrates the utility of this new technology for drug quantitation within a regulated environment. |
|---|---|
| AbstractList | The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity and sensitivity of LC-MS-MS to quantitate trace level components within complex matrices, in particular human plasma. One assay undergoes a validation procedure and demonstrates the utility of this new technology for drug quantitation within a regulated environment. The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity of sensitivity of LC-MS-MS to quantitate trace level components within complex matrices, in particular human plasma. One assay undergoes a validation procedure and demonstrates the utility of this new technology for drug quantitation within a regulated environment. |
| Author | Wu, D. Land, A.P. Lopez, L. Schwartz, J. Cunniff, J. Price, P. Buhrman, D.L. Jardine, I. Wakefield, M. Newton, J.F. Folk, B.M. Burton, R.D. Tiller, P.R. |
| Author_xml | – sequence: 1 givenname: P.R. surname: Tiller fullname: Tiller, P.R. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 2 givenname: J. surname: Cunniff fullname: Cunniff, J. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 3 givenname: A.P. surname: Land fullname: Land, A.P. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 4 givenname: J. surname: Schwartz fullname: Schwartz, J. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 5 givenname: I. surname: Jardine fullname: Jardine, I. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 6 givenname: M. surname: Wakefield fullname: Wakefield, M. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 7 givenname: L. surname: Lopez fullname: Lopez, L. organization: Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134, USA – sequence: 8 givenname: J.F. surname: Newton fullname: Newton, J.F. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA – sequence: 9 givenname: R.D. surname: Burton fullname: Burton, R.D. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA – sequence: 10 givenname: B.M. surname: Folk fullname: Folk, B.M. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA – sequence: 11 givenname: D.L. surname: Buhrman fullname: Buhrman, D.L. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA – sequence: 12 givenname: P. surname: Price fullname: Price, P. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA – sequence: 13 givenname: D. surname: Wu fullname: Wu, D. organization: Sanofi Research Division, 25 Great Valley Parkway, Malvern, PA 19355, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2710119$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/9210315$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkE1LxDAQhnNQ_P4JQg8ieqgm2aZpTiLrJwge1HOYplM30jbdJBX23xvdZa_CQGDeZ2bCc0h2BjcgIaeMXjHKyus3SjnLVSlnF0peUsoKmcsdcrBt75PDEL5SIKnke2RPcUZnTByQjzs_fWbLCYZoI0TrhiwVZDUOZhHdmHV2OdkmMwvveoju08O4WOURhgb7rIcQsjCiiSnF6FdZWIWI_THZbaELeLJ5j8jHw_37_Cl_eX18nt--5GZWqZiLWhSiLIUEJhSTrKCVNG1FW1AGKsqFMUyhMU3Z1EYw4KKoU8iRc1CsqmdH5Hy9d_RuOWGIurfBYNfBgG4KWipGi0qUCRRr0HgXgsdWj9724FeaUf2rUP8p1L-utJL6T6GWae50c2Cqe2y2Uxt_KT_b5BAMdK2HwdiwxbhMu5lK2M0awyTj26LXwdhkGBvrkzzdOPvPR34AakuSXA |
| CODEN | JOCRAM |
| CitedBy_id | crossref_primary_10_1002_mas_10050 crossref_primary_10_1038_nbt1235 crossref_primary_10_1016_S1387_3806_01_00499_7 crossref_primary_10_1021_pr900298b crossref_primary_10_1074_mcp_M700354_MCP200 crossref_primary_10_1016_S0378_4347_99_00147_4 crossref_primary_10_2174_1573412916999200512121023 crossref_primary_10_1021_ac980295n crossref_primary_10_1016_S1570_0232_03_00261_7 crossref_primary_10_1002__SICI_1098_2787_1999_18_3_4_187__AID_MAS2_3_0_CO_2_K crossref_primary_10_2174_1573412916666191111144707 crossref_primary_10_1002_jms_105 crossref_primary_10_1074_jbc_M110_190108 crossref_primary_10_1074_mcp_M700504_MCP200 crossref_primary_10_1021_pr801122b crossref_primary_10_1002_rcm_1257 crossref_primary_10_1021_pr900010h |
| Cites_doi | 10.1021/ac00055a006 10.1002/anie.197605091 |
| ContentType | Journal Article Conference Proceeding |
| Copyright | 1997 Elsevier Science B.V. All rights reserved 1997 INIST-CNRS |
| Copyright_xml | – notice: 1997 Elsevier Science B.V. All rights reserved – notice: 1997 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/S0021-9673(97)00147-7 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EndPage | 125 |
| ExternalDocumentID | 10_1016_S0021_9673_97_00147_7 9210315 2710119 S0021967397001477 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29K 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO AAYJJ ABFNM ABFRF ABJNI ABMAC ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNNM ACRLP ADBBV ADECG ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFZHZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJQLL AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC D-I DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FLBIZ FNPLU FYGXN G-Q G8K GBLVA HMU HVGLF HZ~ H~9 IH2 IHE J1W KOM M36 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCB SCC SCH SDF SDG SDP SES SEW SPC SPCBC SSK SSZ T5K UQL VH1 WH7 WUQ XFK XPP YK3 ZGI ZKB ZMT ZXP ~02 ~G- ~KM 08R AAUGY ABPIF ABPTK IQODW AAHBH AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX ABDPE AFJKZ CITATION 7X8 |
| ID | FETCH-LOGICAL-c389t-5b5456657a1591714087cf80fa9ca8025cc19eccd6dbc51a254b0fa2e22a918b3 |
| ISSN | 0021-9673 |
| IngestDate | Fri Oct 25 05:45:07 EDT 2024 Thu Nov 21 22:32:19 EST 2024 Sat Sep 28 08:40:44 EDT 2024 Sun Oct 22 16:08:12 EDT 2023 Fri Feb 23 02:26:08 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Detection, LC SR 27417 Liquid chromatography-mass spectrometry Steroids Trace analysis Human Steroid Corticosteroid Biological fluid Chemical analysis Coupled method Thiazole derivatives Benzene derivatives HPLC chromatography Blood Blood plasma Pyridine derivatives Mass spectrometry MS/MS Quantitative analysis |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c389t-5b5456657a1591714087cf80fa9ca8025cc19eccd6dbc51a254b0fa2e22a918b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 9210315 |
| PQID | 79104856 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_79104856 crossref_primary_10_1016_S0021_9673_97_00147_7 pubmed_primary_9210315 pascalfrancis_primary_2710119 elsevier_sciencedirect_doi_10_1016_S0021_9673_97_00147_7 |
| PublicationCentury | 1900 |
| PublicationDate | 1997-05-30 |
| PublicationDateYYYYMMDD | 1997-05-30 |
| PublicationDate_xml | – month: 05 year: 1997 text: 1997-05-30 day: 30 |
| PublicationDecade | 1990 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: Netherlands |
| PublicationTitle | Journal of Chromatography A |
| PublicationTitleAlternate | J Chromatogr A |
| PublicationYear | 1997 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Wakefield, Land, Newton, Burton, Folk, Burhrman, Price, Wu (bib5) 1996 Rule, McLaughlin, Henion (bib2) 1993; 65 Levsen, Schwartz Angew (bib3) 1976; 15 Paulson, Cunniff, Schwartz (bib6) 1996 Busch, Glish, McLuckey (bib1) 1988 M. Wakefield, L. Lopez, J. Newton, R. Burton, B. Folk and D. Burhrman, Application report 258, Finnigan Corporation Cunniff, Tiller, Land, Vasconcellos, Wakefield (bib4) 1996 10.1016/S0021-9673(97)00147-7_bib7 Busch (10.1016/S0021-9673(97)00147-7_bib1) 1988 Levsen (10.1016/S0021-9673(97)00147-7_bib3) 1976; 15 Wakefield (10.1016/S0021-9673(97)00147-7_bib5) 1996 Paulson (10.1016/S0021-9673(97)00147-7_bib6) 1996 Rule (10.1016/S0021-9673(97)00147-7_bib2) 1993; 65 Cunniff (10.1016/S0021-9673(97)00147-7_bib4) 1996 |
| References_xml | – volume: 65 start-page: 857A year: 1993 ident: bib2 publication-title: Anal. Chem. contributor: fullname: Henion – start-page: 623 year: 1996 ident: bib4 publication-title: Proceedings of the 44th ASMS Conference of Mass Spectrometry and Allied Topics contributor: fullname: Wakefield – start-page: 1148 year: 1996 ident: bib6 publication-title: Proceedings of the 44th ASMS Conference of Mass Spectrometry and Allied Topics contributor: fullname: Schwartz – year: 1988 ident: bib1 article-title: Mass Spectrometry/Mass Spectrometry: Techniques and Applications of Tandem Mass Spectrometry contributor: fullname: McLuckey – volume: 15 start-page: 509 year: 1976 ident: bib3 publication-title: Chem. Int. Ed. Engl. contributor: fullname: Schwartz Angew – start-page: 615 year: 1996 ident: bib5 publication-title: Proceedings of the 44th ASMS Conference of Mass Spectrometry and Allied Topics contributor: fullname: Wu – start-page: 615 year: 1996 ident: 10.1016/S0021-9673(97)00147-7_bib5 contributor: fullname: Wakefield – ident: 10.1016/S0021-9673(97)00147-7_bib7 – volume: 65 start-page: 857A year: 1993 ident: 10.1016/S0021-9673(97)00147-7_bib2 publication-title: Anal. Chem. doi: 10.1021/ac00055a006 contributor: fullname: Rule – year: 1988 ident: 10.1016/S0021-9673(97)00147-7_bib1 contributor: fullname: Busch – start-page: 623 year: 1996 ident: 10.1016/S0021-9673(97)00147-7_bib4 contributor: fullname: Cunniff – volume: 15 start-page: 509 year: 1976 ident: 10.1016/S0021-9673(97)00147-7_bib3 publication-title: Chem. Int. Ed. Engl. doi: 10.1002/anie.197605091 contributor: fullname: Levsen – start-page: 1148 year: 1996 ident: 10.1016/S0021-9673(97)00147-7_bib6 contributor: fullname: Paulson |
| SSID | ssj0017072 ssj0029838 |
| Score | 1.6843532 |
| Snippet | The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical... |
| SourceID | proquest crossref pubmed pascalfrancis elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 119 |
| SubjectTerms | Analysis Biological and medical sciences Calibration Chromatography, Liquid - methods Detection, LC Gas Chromatography-Mass Spectrometry - methods General pharmacology Humans Hydrocortisone - blood Liquid chromatography-mass spectrometry Mass Spectrometry - methods Medical sciences Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity SR 27417 Steroids Testosterone - blood Thiazoles - analysis |
| Title | Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system |
| URI | https://dx.doi.org/10.1016/S0021-9673(97)00147-7 https://www.ncbi.nlm.nih.gov/pubmed/9210315 https://search.proquest.com/docview/79104856 |
| Volume | 771 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Lb5swGLey9LBJO-zRalnXzYcdNiEyzCPGxy4hSqYuitpG6g0ZMGullaQJHPbf7zM2mL5U7TApQhERhvj74e_n74nQ55zmJPczYtPcS22fJ54dMofZCchaJInIvEzaIWdndHERTiI_6vWaEhvm3H-VNJwDWcvM2X-QdjsonIDvIHM4gtTheF_uD6qfDsdML7droKTdstQaHpNt9UtmVBalLtItvQbcSuCvXJbrjfX76qa6yu4MYEu7g7i2roFxW3WOpix2UG7_6ILQrRlgfnKiIiyWQxOROF4tFvPp9JYv6vtqdvrzuA41mAyt1hC9PJ2PI5N9luk0PVo71B1jKtN6vbv0yliQkepb0iy9VLVfaTCmEyHVUkr0Uqq0MlHp0fcWfGV7OGtHB1ouSwszufWjNjVarvHs31F-bUiiC1SLyPqxe3Wz-D7aO55HFz9ajxR1aFuXzGWhp1S8vqtJDftmHuULo1_1YzxGel5u-A5exVz1UHl8k1OTnfNXaN-kgeJli7DXqCeKN-j5uGkR-BatJIpwF0UYPhw3KMIKRfhBFGGJItxFEVYo2keraXQ-ntm6T4edAt0t7SCRNHwUUA7cmMgKkCFN89DJOUt5CKQ6TQmDpUL2LksDwt3AT-BHV7guZyRMvAPUL9aFeIdwzoMwc1gm7RI-ZSkTGYGREp8J2Mp7ZICGzUTGG1WOJTZxijDzsZz5uA6qgAFiOkBhM92x5pSKK8aAoKcuPbolnvaGGioD9KkRVwzzLh1tvBDrahdT4OB-GIwG6EBJsb2UuXVblfdPDH2IXpiX6gPql9tKHKFnu6z6qHH5F7tlqos |
| link.rule.ids | 310,311,315,782,786,791,792,23939,23940,25149,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Journal+of+chromatography&rft.atitle=Drug+quantitation+on+a+benchtop+liquid+chromatography-tandem+mass+spectrometry+system&rft.au=TILLER%2C+P.+R&rft.au=CUNNIFF%2C+J&rft.au=BUHRMAN%2C+D.+L&rft.au=PRICE%2C+P&rft.date=1997-05-30&rft.pub=Elsevier&rft.issn=0021-9673&rft.volume=771&rft.issue=1-2&rft.spage=119&rft.epage=125&rft_id=info:doi/10.1016%2FS0021-9673%2897%2900147-7&rft.externalDBID=n%2Fa&rft.externalDocID=2710119 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9673&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9673&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9673&client=summon |