Polymerization of individual species of tree pollen allergens

This report describes the preparation of individual tree pollen allergen polymers in contrast to our previous description of the polymerization of a mixture of tree pollens.. These individual polymers may be used for immunotherapy as indicated by the IgE-mediated reactivity of each patient. A modifi...

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Bibliographic Details
Published in:	International archives of allergy and applied immunology Vol. 73; no. 1; p. 1
Main Authors:	Patterson, R, Suszko, I M, Grammer, L C
Format:	Journal Article
Language:	English
Published:	Switzerland 1984
Subjects:	Allergens - administration & dosage Chromatography, Gel Humans Intradermal Tests Macromolecular Substances Molecular Weight Pollen - immunology Rhinitis, Allergic, Seasonal - diagnosis Rhinitis, Allergic, Seasonal - therapy Trees
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Summary:	This report describes the preparation of individual tree pollen allergen polymers in contrast to our previous description of the polymerization of a mixture of tree pollens.. These individual polymers may be used for immunotherapy as indicated by the IgE-mediated reactivity of each patient. A modified chromatographic fractionation process was used which results in tree polymers with skin reactivity 1,000- to 10,000-fold less from monomers and with a defined lower molecular weight limit. The modified preparative methodology results in polymer preparations as safe but with greater ease of production than polymers prepared with previous methodologies.
ISSN:	0020-5915
DOI:	10.1159/000233427