Modulation of intracellular calcium homeostasis blocks autophagosome formation

Cellular stress responses often involve elevation of cytosolic calcium levels, and this has been suggested to stimulate autophagy. Here, however, we demonstrated that agents that alter intracellular calcium ion homeostasis and induce ER stress-the calcium ionophore A23187 and the sarco/endoplasmic r...

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Bibliographic Details
Published in:	Autophagy Vol. 9; no. 10; pp. 1475 - 1490
Main Authors:	Engedal, Nikolai, Torgersen, Maria L, Guldvik, Ingrid J, Barfeld, Stefan J, Bakula, Daniela, Sætre, Frank, Hagen, Linda K, Patterson, John B, Proikas-Cezanne, Tassula, Seglen, Per O, Simonsen, Anne, Mills, Ian G
Format:	Journal Article
Language:	English
Published:	United States 01-10-2013
Subjects:	Autophagy - drug effects Calcium - metabolism Cell Communication - drug effects Cell Communication - physiology Cell Line Cytosol - metabolism Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Homeostasis - drug effects Humans Intracellular Space - metabolism Signal Transduction - drug effects Thapsigargin - pharmacology autophagy calcium long-lived protein degradation sequestration ER stress autophagosome formation A23187 thapsigargin
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