Methanol inhalation toxicity
Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%). Patients arrived at the emer...
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| Published in: | Annals of emergency medicine Vol. 22; no. 12; p. 1919 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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United States
01-12-1993
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| Abstract | Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%). Patients arrived at the emergency department with central nervous system depression, nausea, vomiting, shortness of breath, photophobia, and/or decreased visual acuity. Treatment included correction of acidosis, leucovorin and/or folic acid, ethanol infusions, and supportive care. Hemodialysis was necessary in three cases. Measured blood methanol levels ranged from 50.4 to 128.6 mg/dL. Blood formic acid levels were 120, 193, and 480 micrograms/mL, respectively, in three patients. Ophthalmic examinations revealed hyperemic discs and decreased visual acuity in one patient. One individual was found pulseless with several CARB-MEDIC cans nearby. Attempts at revival were unsuccessful. Clinicians should be aware that significant blood methanol and formic acid levels may occur after inhalation of methanol. |
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| AbstractList | Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%). Patients arrived at the emergency department with central nervous system depression, nausea, vomiting, shortness of breath, photophobia, and/or decreased visual acuity. Treatment included correction of acidosis, leucovorin and/or folic acid, ethanol infusions, and supportive care. Hemodialysis was necessary in three cases. Measured blood methanol levels ranged from 50.4 to 128.6 mg/dL. Blood formic acid levels were 120, 193, and 480 micrograms/mL, respectively, in three patients. Ophthalmic examinations revealed hyperemic discs and decreased visual acuity in one patient. One individual was found pulseless with several CARB-MEDIC cans nearby. Attempts at revival were unsuccessful. Clinicians should be aware that significant blood methanol and formic acid levels may occur after inhalation of methanol. |
| Author | Schauben, J L Frenia, M L |
| Author_xml | – sequence: 1 givenname: M L surname: Frenia fullname: Frenia, M L organization: Florida Poison Information Center/Clinical Toxicology Service, University Medical Center-Jacksonville – sequence: 2 givenname: J L surname: Schauben fullname: Schauben, J L |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8239117$$D View this record in MEDLINE/PubMed |
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| Snippet | Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC... |
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| SubjectTerms | Administration, Inhalation Adult Ethanol - therapeutic use Folic Acid - therapeutic use Humans Leucovorin - therapeutic use Male Methanol - poisoning Poisoning - drug therapy Substance-Related Disorders |
| Title | Methanol inhalation toxicity |
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