Methanol inhalation toxicity

Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%). Patients arrived at the emer...

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Bibliographic Details
Published in:	Annals of emergency medicine Vol. 22; no. 12; p. 1919
Main Authors:	Frenia, M L, Schauben, J L
Format:	Journal Article
Language:	English
Published:	United States 01-12-1993
Subjects:	Administration, Inhalation Adult Ethanol - therapeutic use Folic Acid - therapeutic use Humans Leucovorin - therapeutic use Male Methanol - poisoning Poisoning - drug therapy Substance-Related Disorders
Online Access:	Get more information
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Summary:	Significant toxicity can result from intentional methanol inhalation. We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%). Patients arrived at the emergency department with central nervous system depression, nausea, vomiting, shortness of breath, photophobia, and/or decreased visual acuity. Treatment included correction of acidosis, leucovorin and/or folic acid, ethanol infusions, and supportive care. Hemodialysis was necessary in three cases. Measured blood methanol levels ranged from 50.4 to 128.6 mg/dL. Blood formic acid levels were 120, 193, and 480 micrograms/mL, respectively, in three patients. Ophthalmic examinations revealed hyperemic discs and decreased visual acuity in one patient. One individual was found pulseless with several CARB-MEDIC cans nearby. Attempts at revival were unsuccessful. Clinicians should be aware that significant blood methanol and formic acid levels may occur after inhalation of methanol.
ISSN:	0196-0644
DOI:	10.1016/S0196-0644(05)80424-X