CYP1A2 is expressed along with CYP1A1 in the human lung

The expression and activity of CYP1A1 were examined in fresh, small-sized lung biopsy specimens from nine human subjects. CYP1A1 transcripts were detected by reverse transcription-polymerase chain reaction (RT-PCR) analysis of total lung RNA. CYP1A2 transcripts were detected in the RNA samples as we...

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Bibliographic Details
Published in:	Cancer letters Vol. 164; no. 1; pp. 25 - 32
Main Authors:	Wei, Cindy, Cacavale, Robert J., Kehoe, John J., Thomas, Paul E., Iba, Michael M.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 10-03-2001 Elsevier
Subjects:	2-Amino-3,4-dimethylimidazo[4,5-f]quinoline Analytical, structural and metabolic biochemistry Animals Antibodies, Monoclonal - metabolism Benzo(a)pyrene - metabolism Benzo[ a]pyrene Biological and medical sciences Blotting, Western CYP1A1 CYP1A2 Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - biosynthesis Cytochrome P-450 CYP1A2 - metabolism Dose-Response Relationship, Drug Enzymes and enzyme inhibitors Fluorenes - metabolism Fundamental and applied biological sciences. Psychology Human lung Humans Lung - metabolism Mice mRNA Mutagenicity Mutagenicity Tests Mutagens - metabolism Oxidoreductases Protein Quinolines - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Human lung 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline CYP1A2 CYP1A1 Benzo[ a]pyrene mRNA Mutagenicity Protein Surgical biopsy Human Enzyme Isozyme Gene product Mutagenicity testing Cytochrome P450 Lung Gene expression In vitro Tissue Ames test Metabolic activation Drug-metabolizing enzyme
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