HOMOCYSTEINE IN GREENLAND INUITS

• Published in: Thrombosis research Vol. 86; no. 4; pp. 333 - 335
• Main Authors: Møller, J.M, Nielsen, G.L, Ekelund, S, Schmidt, E.B, Dyerberg, J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15-05-1997; Elsevier Science
• Subjects: Adult; Aged; Arteriosclerosis - prevention & control; Biological and medical sciences; Denmark; Diet; Fatty Acids, Omega-3 - blood; Female; Greenland; Homocysteine; Homocysteine - blood; Human physiology applied to population studies and life conditions. Human ecophysiology; Humans; Inuits; Male; Medical sciences; Middle Aged; n-3 PUFA; Nutritional survey. Food supply and nutritional requirement; North America; Greenland; America; Denmark; Homocysteine; n-3 PUFA; Inuits; Human; Nutrition; Diet; Polyunsaturated fatty acid; n-3 fatty acid; Nutritional status; Blood plasma
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(97)00076-5

Patients with homozygous homocystinuria are at greatly increased risk for development of atherosclerosis and thrombosis
[1]. Elevated plasma levels of homocysteine (HCY) are caused by reduced enzymatic catabolism or reduced enzymatic remethylation of HCY, due to either hereditary enzyme defects or to nutrional deficiencies of vitamins functioning as cofactors. However, several recent studies have suggested that persons with mildly elevated plasma levels of HCY also are at increased risk for coronary heart disease.
[2–4].
There are some indications that dietary n-3 polyunsaturated fatty acids (PUFAs) may offer protection against coronary heart disease
[5, 6]. Several mechanisms may be involved, including beneficial effects of n-3 PUFAs on plasma lipids, platelet and leukocyte reactivity, blood pressure and vasoreactivity
[7]. Interestingly, Olszewski et al. recently found HCY-levels to be lowered 36% in 15 type IIa or IIb hyperlipemic men by n-3 PUFA supplementation.
A possible beneficial effect of n-3 PUFA on the incidence of coronary heart disease was initially suggested from studies in Greenland Inuits by our group
[8]. We therefore investigated plasma levels of homocystein in a group of traditionally living Greenland Inuits with a diet consisting mainly of marine food and with a very high content of n-3 PUFAs. ©
1997 Elsevier Science Ltd