Rubiadin exerts an acute and chronic anti-inflammatory effect in rodents

• Published in: Brazilian journal of biology Vol. 83; pp. e243775 - 8
• Main Authors: Chitsaz, Romina, Zarezadeh, Atefeh, Asgarpanah, Jinous, Najafizadeh, Parvaneh, Mousavi, Zahra
• Format: Journal Article
• Language: English
• Published: Brazil Instituto Internacional de Ecologia 2023
• Subjects: Animal models; Animals; Anthraquinone; Anthraquinones; anti-inflammatory; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; BIOLOGY; Cancer; Carrageenan; Carrageenan - therapeutic use; Carrageenan - toxicity; Carrageenans; Cotton; Edema; Edema - chemically induced; Edema - drug therapy; Granuloma; Granulomas; Herbal medicine; IL-1β; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Laboratory animals; Mefenamic acid; Pellets; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Quinones; Rats; Rodentia; Rodents; Rubiadin; TNF α; Tumor necrosis factor-α; Variance analysis; Iran; United States > US; anthraquinone; Rubiadina; anti-inflamatório; anti-inflammatory; TNF α; antraquinona; Rubiadin; IL-1β
• ISSN: 1519-6984; 1678-4375; 1678-4375
• DOI: 10.1590/1519-6984.243775

Rubiadin is identified as a bioactive anthraquinone that exists in some quinone rich plants. The current research was carried out to evaluate the potential anti-inflammatory impact of Rubiadin in acute and chronic inflammation test models in rodents. The anti-inflammatory activity of Rubiadin was examined in cotton pellet-induced granuloma and carrageenan-induced edema as chronic and acute inflammation models in rats. TNF-α level and histopathological changes were assessed using sampled foot tissue of rat in the acute model. Also, the IL-1β level was assessed in the chronic model. One-way ANOVA (post hoc Tukey's) analysis was used for comparing the groups. Rubiadin (0.5 mg/kg, i.p.) induced a significant reduction in TNF α level and the paw edema compared to the control group in carrageenan test. Also, it was observed that the anti-inflammatory activity of Rubiadin (0.5 mg/kg, i.p.) is comparable to mefenamic acid (30 mg/kg, i.p.) as the standard drug. Rubiadin was effective in granuloma induced by cotton pellet concerning the granuloma and transudate formation amount. Rubiadin's anti-inflammatory effects were associated with a significant IL-1β decrease in this model. The results suggest that Rubiadin as a natural compound can possess significant peripheral anti-inflammatory impacts.