Latent HSV 1 virus in trigeminal ganglia: the optimal site for linking prevention of Alzheimer's disease to vaccination

If the pathogenetic cascade occurring in the human brain eventuating in dementia of the Alzheimer type is proven to be triggered by latent Herpes simplex virus Type 1 in the human central nervous system, the suggestion by Itzhaki et al. that mice vaccinated with mixed HSV-1 glycoproteins incorporate...

Full description

Saved in:

Bibliographic Details
Published in:	Neurobiology of aging Vol. 22; no. 5; pp. 705 - 709
Main Authors:	Ball, M J, Mathews, R, Steiner, I, Hill, J M, Wisner, T W, Murdoch, G H, Kohama, S, Sexton, G, Nagalla, S
Format:	Journal Article
Language:	English
Published:	United States 01-09-2001
Subjects:	Alzheimer Disease - prevention & control Alzheimer Disease - virology Animals Herpes Simplex - complications Herpes Simplex - prevention & control Herpes simplex virus 1 Herpesvirus 1, Human - immunology Herpesvirus Vaccines Humans Trigeminal Neuralgia - virology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	If the pathogenetic cascade occurring in the human brain eventuating in dementia of the Alzheimer type is proven to be triggered by latent Herpes simplex virus Type 1 in the human central nervous system, the suggestion by Itzhaki et al. that mice vaccinated with mixed HSV-1 glycoproteins incorporated into immunostimulating complexes (ISCOM) carrier adjuvant can be protected against latent HSV-1 might have enormous therapeutic implications for cognitive decline amongst the elderly.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Commentary-2 ObjectType-Feature-4 ObjectType-Review-1 ObjectType-Article-3
ISSN:	0197-4580
DOI:	10.1016/S0197-4580(01)00253-6