Assignment of defensin gene(s) to human chromosome 8p23

A relatively abundant component of the polymorphonuclear leukocyte granulocytes has been recently isolated and called defensin. Defensins have antimicrobial activity against gram-positive and gram-negative bacteria and enveloped viruses. A cDNA insert for defensin HNP-1 (DEF1) has been used to map t...

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Bibliographic Details
Published in:	Genomics (San Diego, Calif.) Vol. 5; no. 2; p. 240
Main Authors:	Sparkes, R S, Kronenberg, M, Heinzmann, C, Daher, K A, Klisak, I, Ganz, T, Mohandas, T
Format:	Journal Article
Language:	English
Published:	United States 01-08-1989
Subjects:	alpha-Defensins Animals Blotting, Southern Chromosome Mapping Chromosomes, Human, Pair 8 - ultrastructure Humans Hybrid Cells In Vitro Techniques Mice Neutrophils - physiology Proteins - genetics
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Summary:	A relatively abundant component of the polymorphonuclear leukocyte granulocytes has been recently isolated and called defensin. Defensins have antimicrobial activity against gram-positive and gram-negative bacteria and enveloped viruses. A cDNA insert for defensin HNP-1 (DEF1) has been used to map the gene(s) to human chromosome 8p23 using a mouse/human somatic cell hybrid panel and in situ hybridization to normal human metaphase chromosomes. Because of the similarity of HNP-1 defensin to other defensins, it is likely that two of these genes map to this region.
ISSN:	0888-7543
DOI:	10.1016/0888-7543(89)90052-9