Application of the Folin-Ciocalteau reagent to the determination of salbutamol in pharmaceutical preparations

Application of the Folin-Ciocalteau reagent to the determination of salbutamol in pharmaceutical preparations

A method for the determination of salbutamol in both tablets and syrups is described. It utilizes the reduction of the Folin-Ciocalteau reagent by the phenolic group, monitoring the absorbance of the resulting complex at 760 nm. Results obtained are linear over the range 0–6 μg ml −1 salbutamol. Col...

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Bibliographic Details
Published in:Talanta (Oxford) Vol. 42; no. 10; pp. 1385 - 1388
Main Authors: Sadler, Novelette P., Jacobs, Helen
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 01-10-1995
Oxford Elsevier
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Anion exchange
Chemical analysis
Bronchodilator
Dosage form
β2-Adrenergic receptor
Colorimetry
Tablet
Syrup
Quantitative analysis
Ion exchange chromatography
Ultraviolet visible spectrometry
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Summary:A method for the determination of salbutamol in both tablets and syrups is described. It utilizes the reduction of the Folin-Ciocalteau reagent by the phenolic group, monitoring the absorbance of the resulting complex at 760 nm. Results obtained are linear over the range 0–6 μg ml −1 salbutamol. Coloring material was removed by anionexchange chromatography prior to analysis and there was no interference from sucrose, neutral flavorings or the common preservative sodium benzoate. This method appears suitable as a general assay for salbutamol.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(95)01534-I