Erythrocyte membrane lysophospholipase activity in muscular dystrophy

The membrane lysophospholipase activity of erythrocytes obtained from Duchenne muscular dystrophy patients was lower than that of erythrocytes from age-matched normal boys. On the other hand, the membrane enzyme activity of erythrocytes from myotonic dystrophy patients was not different from that of...

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Published in:	Journal of the neurological sciences Vol. 59; no. 3; p. 423
Main Authors:	Podolski, J L, Lubansky, H J, Sarpel, G, Danon, M J, Lazowski, E, Omachi, A
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-1983
Subjects:	Dipyridamole - pharmacology Enzyme Activation - drug effects Erythrocyte Membrane - enzymology Erythrocytes - enzymology Glycerylphosphorylcholine - pharmacology Humans Lysophospholipase - metabolism Muscular Dystrophies - enzymology Myotonic Dystrophy - enzymology Phospholipases - metabolism
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Abstract	The membrane lysophospholipase activity of erythrocytes obtained from Duchenne muscular dystrophy patients was lower than that of erythrocytes from age-matched normal boys. On the other hand, the membrane enzyme activity of erythrocytes from myotonic dystrophy patients was not different from that of their age- and sex-matched controls. Dipyridamole (0.1 mM) and glycerol 3-phosphorylcholine (2 mM) had no significant effect on these enzyme activities. These results suggest that membrane lysophospholipid metabolism may be altered in Duchenne muscular dystrophy but not in myotonic dystrophy.
AbstractList	The membrane lysophospholipase activity of erythrocytes obtained from Duchenne muscular dystrophy patients was lower than that of erythrocytes from age-matched normal boys. On the other hand, the membrane enzyme activity of erythrocytes from myotonic dystrophy patients was not different from that of their age- and sex-matched controls. Dipyridamole (0.1 mM) and glycerol 3-phosphorylcholine (2 mM) had no significant effect on these enzyme activities. These results suggest that membrane lysophospholipid metabolism may be altered in Duchenne muscular dystrophy but not in myotonic dystrophy.
Author	Sarpel, G Omachi, A Lazowski, E Podolski, J L Lubansky, H J Danon, M J
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/6875608$$D View this record in MEDLINE/PubMed
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SubjectTerms	Dipyridamole - pharmacology Enzyme Activation - drug effects Erythrocyte Membrane - enzymology Erythrocytes - enzymology Glycerylphosphorylcholine - pharmacology Humans Lysophospholipase - metabolism Muscular Dystrophies - enzymology Myotonic Dystrophy - enzymology Phospholipases - metabolism
Title	Erythrocyte membrane lysophospholipase activity in muscular dystrophy
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