Erythrocyte membrane lysophospholipase activity in muscular dystrophy

• Published in: Journal of the neurological sciences Vol. 59; no. 3; p. 423
• Main Authors: Podolski, J L, Lubansky, H J, Sarpel, G, Danon, M J, Lazowski, E, Omachi, A
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-1983
• Subjects: Dipyridamole - pharmacology; Enzyme Activation - drug effects; Erythrocyte Membrane - enzymology; Erythrocytes - enzymology; Glycerylphosphorylcholine - pharmacology; Humans; Lysophospholipase - metabolism; Muscular Dystrophies - enzymology; Myotonic Dystrophy - enzymology; Phospholipases - metabolism
• ISSN: 0022-510X
• DOI: 10.1016/0022-510X(83)90027-8

The membrane lysophospholipase activity of erythrocytes obtained from Duchenne muscular dystrophy patients was lower than that of erythrocytes from age-matched normal boys. On the other hand, the membrane enzyme activity of erythrocytes from myotonic dystrophy patients was not different from that of their age- and sex-matched controls. Dipyridamole (0.1 mM) and glycerol 3-phosphorylcholine (2 mM) had no significant effect on these enzyme activities. These results suggest that membrane lysophospholipid metabolism may be altered in Duchenne muscular dystrophy but not in myotonic dystrophy.