HLA and systemic lupus erythematosus in Chinese

Seventy-five unrelated Chinese SLE patients were HLA typed and subdivided into mild and severe disease. The HLA-B13 was associated with mild disease. Fourteen of 30 (46.7%) mild disease patients had B13 compared to 63/330 (19.1%) normal subjects (p less than 0.0005, corrected p less than 0.013, RR =...

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Bibliographic Details
Published in:	Human immunology Vol. 3; no. 4; p. 345
Main Authors:	Chan, S H, Feng, P H, Srinivasan, N, Wee, G B, Chan, H C
Format:	Journal Article
Language:	English
Published:	United States 01-01-1981
Subjects:	China HLA Antigens - genetics HLA Antigens - immunology Humans Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - mortality China
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Summary:	Seventy-five unrelated Chinese SLE patients were HLA typed and subdivided into mild and severe disease. The HLA-B13 was associated with mild disease. Fourteen of 30 (46.7%) mild disease patients had B13 compared to 63/330 (19.1%) normal subjects (p less than 0.0005, corrected p less than 0.013, RR = 3.7). The HLA-B17 on the other hand was observed in 29% of 45 severe disease patients compared to 13.9% of 330 normal subjects (p less than 0.01, RR = 2.5). The frequency of HLA-B17 in 11 patients who died was even higher (45.5%).
ISSN:	0198-8859
DOI:	10.1016/0198-8859(81)90070-7