QKI, a miR‐200 target gene, suppresses epithelial‐to‐mesenchymal transition and tumor growth

The microRNA‐200 (miR‐200) family plays a major role in specifying epithelial phenotype by preventing expression of the transcription repressors ZEB1 and ZEB2, which are well‐known regulators of the epithelial‐to‐mesenchymal transition (EMT) in epithelial tumors including oral squamous cell carcinom...

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Bibliographic Details
Published in:	International journal of cancer Vol. 145; no. 6; pp. 1585 - 1595
Main Authors:	Kim, Eun Ju, Kim, Jeong Seon, Lee, Sieun, Lee, Heejin, Yoon, Jung‐Sook, Hong, Ji Hyung, Chun, Sang Hoon, Sun, Der Sheng, Won, Hye Sung, Hong, Soon Auck, Kang, Keunsoo, Jo, Jeong Yeon, Choi, Minyoung, Shin, Dong Hoon, Ahn, Young‐Ho, Ko, Yoon Ho
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 15-09-2019 Wiley Subscription Services, Inc
Subjects:	3' Untranslated Regions Adenocarcinoma Animals Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell Line, Tumor Cell lines Cell migration Cell Proliferation - genetics Epithelial-Mesenchymal Transition - genetics epithelial‐to‐mesenchymal transition Feedback loops Female Gene Expression Gene Knockdown Techniques Genomes Head & neck cancer Heterografts Humans Inflammation Mediators - metabolism Lung cancer Lungs Medical research Mesenchyme Mice Mice, Inbred BALB C MicroRNAs - genetics miRNA miRNA‐200 Mouth Neoplasms - genetics Mouth Neoplasms - pathology Negative feedback Oral cancer Oral squamous cell carcinoma Phenotypes Prognosis QKI Regulators Repressors RNA-binding protein RNA-Binding Proteins - genetics Squamous cell carcinoma Transcription factors Tumor suppressor genes Tumorigenesis Tumors lung cancer QKI miRNA-200 oral cancer epithelial-to-mesenchymal transition
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