The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization

Kappa‐opioid receptors (KOR) control dopamine (DA) levels in the striatum and contribute significantly to the progression of drug addiction. Repeated exposure to psychostimulants has been associated with up‐regulated KOR activity and increased DA levels in dorsal striatum. However, it has not been t...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 148; no. 3; pp. 348 - 358
Main Authors:	Azocar, Victor Hugo, Sepúlveda, Gladys, Ruiz, Catalina, Aguilera, Consuelo, Andrés, Maria Estela, Fuentealba, José Antonio
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-02-2019
Subjects:	amphetamine sensitization Amphetamines Attenuation Caudate-putamen Dopamine dorsolateral striatum Drug abuse Drug addiction Exposure kappa‐opioid receptor Microdialysis Narcotics Neostriatum no‐net flux microdialysis Opioid receptors (type kappa) Perfusion Receptors kappa-opioid receptor dorsolateral striatum no-net flux microdialysis dopamine amphetamine sensitization
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