In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats

This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) mal...

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Bibliographic Details
Published in:	Archives of toxicology Vol. 80; no. 9; pp. 620 - 631
Main Authors:	ABOU-DONIA, Mohamed B, KHAN, Wasiuddin A, DECHKOVSKAIA, Anjelika M, GOLDSTEIN, Larry B, BULLMAN, Sarah L, ABDEL-RAHMAN, Ali
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-09-2006 Springer Nature B.V
Subjects:	Administration, Topical Animals Behavior, Animal - drug effects Biological and medical sciences Cell Death - drug effects Chlorpyrifos - toxicity Cholinesterase Inhibitors - toxicity Cholinesterases - blood Drug Therapy, Combination Female Genetics Infusion Pumps, Implantable Injections, Subcutaneous Male Maternal Exposure - adverse effects Medical sciences Nicotine - toxicity Pesticides, fertilizers and other agrochemicals toxicology Pregnancy Prenatal Exposure Delayed Effects Psychomotor Performance - drug effects Purkinje Cells - drug effects Purkinje Cells - pathology Rats Rodents Tobacco, tobacco smoking Toxicology Cerebellum Developmental Insecticide Rat Central nervous system Purkinje neuron Esterases Acetylcholinesterase Encephalon Alkaloid Mother Purkinje cells Development Adult Behavior Human Chlorpyrifos Behavioral Maternal Enzyme Glial fibrillary acidic protein Pesticides Rodentia Exposure In utero Carboxylic ester hydrolases Pregnancy Progeny Vertebrata Offspring Mammalia Adult animal Hydrolases Organophosphorus compounds Nicotine
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