Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with...

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Bibliographic Details
Published in:	Journal of neurovirology Vol. 25; no. 1; pp. 133 - 136
Main Authors:	Classen, G., Classen, C., Bernasconi, C., Brandt, C., Gold, R., Chan, A., Hoepner, R.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-02-2019
Subjects:	Biomedical and Life Sciences Biomedicine Case Report Immunology Infectious Diseases Neurology Neurosciences Virology Screening Multiple sclerosis Pharmacovigilance Natalizumab EEG John Cunningham virus encephalopathy
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Summary:	Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1355-0284 1538-2443
DOI:	10.1007/s13365-018-0689-2