A flow-based synthesis of imatinib: the API of Gleevec

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure w...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 46; no. 14; p. 2450
Main Authors:	Hopkin, Mark D, Baxendale, Ian R, Ley, Steven V
Format:	Journal Article
Language:	English
Published:	England 01-01-2010
Subjects:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Benzamides Dimethylamines - chemistry Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Piperazines - chemical synthesis Piperazines - chemistry Piperazines - therapeutic use Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - therapeutic use
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Summary:	A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.
ISSN:	1364-548X
DOI:	10.1039/c001550d