Prognostic significance of the prognostic nutritional index in esophageal cancer patients undergoing neoadjuvant chemotherapy

• Published in: Diseases of the esophagus Vol. 30; no. 8; pp. 1 - 7
• Main Authors: Nakatani, M., Migita, K., Matsumoto, S., Wakatsuki, K., Ito, M., Nakade, H., Kunishige, T., Kitano, M., Kanehiro, H.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01-08-2017
• Subjects: Aged; Antineoplastic Agents - administration & dosage; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - surgery; Chemotherapy, Adjuvant - methods; Chemotherapy, Adjuvant - statistics & numerical data; Esophageal Neoplasms - blood; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma; Esophagectomy - methods; Esophagectomy - statistics & numerical data; Female; Humans; Lymphocyte Count; Male; Middle Aged; Neoadjuvant Therapy - methods; Neoadjuvant Therapy - statistics & numerical data; Nutrition Assessment; Nutritional Status; Preoperative Period; Prognosis; Retrospective Studies; Serum Albumin - analysis; Treatment Outcome; neoadjuvant chemotherapy; prognostic nutritional index; Esophageal cancer
• ISSN: 1120-8694; 1442-2050
• DOI: 10.1093/dote/dox020

SUMMARY
Nutritional status is one of the most important issues faced by cancer patients. Several studies have shown that a low preoperative nutritional status is associated with a worse prognosis in patients with various types of cancer, including esophageal cancer (EC). Recently, neoadjuvant chemotherapy (NAC) and/or radiotherapy have been accepted as the standard treatment for resectable advanced EC. However, NAC has the potential to deteriorate the nutritional status of a patient. This study aimed to evaluate the prognostic significance of the nutritional status for EC patients who underwent NAC. We retrospectively reviewed 66 squamous cell EC patients who underwent NAC consisting of docetaxel, cisplatin, and 5-fluorouracil followed by subtotal esophagectomy at Nara Medical University Hospital between January 2009 and August 2015. To assess the patients’ nutritional status, the prognostic nutritional index (PNI) before commencing NAC and prior to the operation was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count in the peripheral blood (per mm3). The cutoff value of the PNI was set at 45. A multivariable analysis was performed to identify prognostic factors for overall survival (OS) and relapse-free survival (RFS). The mean pre-NAC and preoperative PNI were 50.2 ± 5.7 and 48.1 ± 4.7, respectively (P = 0.005). The PNI decreased following NAC in 44 (66.7%) patients. Before initiating NAC, 9 (13.6%) patients had a low PNI, and 12 (18.2%) patients had a low PNI prior to the operation. The pre-NAC PNI and preoperative PNI were significantly associated with the OS (P = 0.013 and P = 0.004, respectively) and RFS (P = 0.036 and P = 0.005, respectively) rates. The multivariable analysis identified the preoperative PNI as an independent prognostic factor for poor OS and RFS, although the pre-NAC PNI was not an independent predictor. Our results suggest that the preoperative PNI is a useful marker for predicting the long-term outcomes of EC patients undergoing NAC and subsequent subtotal esophagectomy. Therefore, patients with a low preoperative nutritional status may be at a higher risk of EC recurrence.