Inhibition of cAMP Phosphodiesterase by Some Phototherapeutic Agents

The behaviour of cyclic-3′,5′-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) (usu ally used in PUVA therapy), 4.6,4′-trimethylangelicin (TMA) and khellin recently proposed for the same thera peutical use. TMP and TMA e...

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Bibliographic Details
Published in:	Zeitschrift für Naturforschung C. A journal of biosciences Vol. 42; no. 7; pp. 1009 - 1010
Main Authors:	Bovalini, Lucia, Lusini, Paola, Simoni, Sandra, Vedaldi, Daniela, Andreassi, Lucio, Dall’Acqua, Francesco, Martelli, Paola
Format:	Journal Article
Language:	English
Published:	Germany Verlag der Zeitschrift für Naturforschung 01-08-1987
Subjects:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Cyclic AMP Phosphodiesterase Furo-chromones Furocoumarins Furocoumarins - pharmacology Khellin - pharmacology Kinetics Liver - enzymology Psoriasis PUVA Therapy Rats Structure-Activity Relationship
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Summary:	The behaviour of cyclic-3′,5′-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) (usu ally used in PUVA therapy), 4.6,4′-trimethylangelicin (TMA) and khellin recently proposed for the same thera peutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0939-5075 1865-7125
DOI:	10.1515/znc-1987-7-849