Action of diclofenac sodium on the reparation process of the surgically-perforated myometrium of pregnant albino rats: morphological and morphometrical evaluation

• Published in: General pharmacology Vol. 25; no. 5; p. 989
• Main Authors: Abdalla, A E, Simões, M de J, Mora, O A, Focchi, G R, Kulay Júnior, L
• Format: Journal Article
• Language: English
• Published: England 01-09-1994
• Subjects: Animals; Collagen - analysis; Diclofenac - pharmacology; Female; Fibroblasts - drug effects; Leukocyte Count; Myometrium - drug effects; Myometrium - pathology; Myometrium - physiology; Pregnancy; Pregnancy, Animal - physiology; Rats; Rats, Wistar
• ISSN: 0306-3623
• DOI: 10.1016/0306-3623(94)90108-2

1. The action of a non-hormonal anti-inflammatory agent on the reparation process of the surgically-perforated myometrium of pregnant albino rats was histologically evaluated. 2. On the 14th day after perforation, the muscular layers were still interrupted. 3. The morphological study was inconclusive. A morphometrical analysis, however, demonstrated that there was a meaningful diminution in the number of leucocytes and collagen fibers and an increase in the number of fibroblasts, probably with low synthetical power, in the group treated with diclofenac sodium. All these data indicate a delay in the reparation process of the uterine musculature.